180276. lajstromszámú szabadalom • Eljárás oleandomicin-származékok előállítására

130.276

Példa

Z

Olvadáspont

/c6/

NMR <f\

rMs

SDClj

7.-0H2-/2-CH3C6H^/

182,5—186

7,28 /s,4H/, 3,66 /s,2H/, 2,68 /m,2H/j 2,06 /s,3H/.

5,63 /d,lH/, 3,40 /s,3H/, 2,36 /s,9H/,

8.-CH2-/4-H0C6H4/

fehéi* hab

7,03 /q,4H/, 3,63 /s,2H/, 2,70 /m,2H/, 2,10 /s,3H/.

6,00 /d,1H/, 3,43 /s,3H/, 2,38 /a,6H/,

9.-CH2-/2~CH30C6H4/

122-126

7,05 /m,4H/, 3,88 /s,3H/,

3.31 /s,3H/,

2.31 /s,6H/,

5,88 /d,1H/, 3,56 /bs,2H/, 2,61 /m,2H/, 2,05 /s,3H/,

10.-ch2-/3-ch3oc6h^/

136,5-139,5

7,13 /m,4H/, 3,86 /s,3H/, 3,41 / a ,3H/, 2,36 /a,6H/,

5,91 /d,lH/, 3,66 /s,2H/, 2,68 /m,2H/, 2,11 /a,3H/s

11.-CH2-/4-CH3006H4/

109-112

7,10 /q ,4H/ , 3,85 /s,3H/, 3,41 /s,3H/, 2,35 /s,6H/,

5,88 /d, 1H/, 3,61 /s,2H/, 2,65 /m,2H/, 2,08 /s,3H/.

12.-CH/C1/-C6H5

/Isi R,S keverék; fehér hab/

7,43 /bs,5H/,5,33 /s,lH/, 3,40 /s ,1,5H/, 3,33 /s,1,5H/, 2,66 /m,2H/, 2,30 /s,6H/, 2,06 /s,3H/.

13 c

2-tenilcsoport

128-131

7,13 /m,3H/, 3,83 /s,2H/, 2,61 /m,2H/, 2,05 /a,3H/.

5,85 /d,1H/, 3,38 /s,3H/, 2,35 /s,6H/,

14.

3-tenilesöpört

/s/

7,16 /m,3H/,

3.63 /s,2H/,

2.63 /m,2H/, 2,06 /s,3H/.

5,90 /d,m/, 3,36 /s,3H/, 2,33 /af6H/,

15.

2-pir id i 1-tne t i 1- csoport

123,5-127,5

8,65 /d,1H/, 3,86 /s,2H/, 2,70 /m,2H/, 2,10 /s,3H/.

7,51 /m,4H/, 3,40 /s,3H/, 3,36 /m,6H/,

16.

3-piridil-meti l'es oport

157-160

8,60 /m,2H/, 6,28 /d,1H/, 3,41 / s, 3H/, 2,36 /s,6H/,

7,73 /m,2H/, 3,66 /s,2H/, 2,68 /m,2H/, 2,06 /s,3H/.

17.

1-tetrazolil-metilcsoport

142-146 /b/

8,96 /s,lH/, 2,70 /m,2H/, 2,03 /s,3H/*

3,33 /s,3H/, 2,30 /s,6H/,

10