Antall József szerk.: Orvostörténeti közlemények 87-88. (Budapest, 1979)

TANULMÁNYOK - Czeizel, Endre: A heredodegeneraciós tan történeti értékelése (angol nyelven)

this clinical picture with Károly Csörsz's name. Thus in V. A. McKusick's well-known handbook of "Mendelian inheritance in man" the representation of the X-linked type of ichthyosis starts with the name Czorsz". Researches after World War II then proved right that ichthyosis vulgaris of the X-linked recessive and of the autosomal dominant type of inheritance are different clinical pictures with regard to the time of appearance, clinical symptoms and pathohistologic characteristics. Csörsz was among the first "splitters" to prove that genetic analysis may serve as a basis for aetiologic Fig. 5. Károly Csörsz (1892-1935) differential diagnosis of seemingly identical clinical pictures. Since then, the localisation of the locus of X-linked ichthyosis within the X-chromosome and its linkage to other genes have been exactly defined. In 1978 even its intrauterine foetal diagnostics was solved. Károly Csörsz proved with another famous pedigree description the autosomal recessive inheritance of different loci of deaf-mutism (fig. 7.). In the 1930-s

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