Fogorvosi szemle, 2009 (102. évfolyam, 1-6. szám)
2009-04-01 / 2. szám
68 FOGORVOSI SZEMLE ■ 102. évf. 2. sz. 2009. 24. Mealey BL, Moritz AJ: Hormonal influences: effects of diabetes mellitus and endogenous female sex steroid hormones on the periodontium. Periodontology 2000, 2003; 32: 59-81. 25. Neville BW, Day TA: Tumors and precancerous lesions of the oral cavity. CA Cancer J Clin 2002; 52: 195-215. 26. Newman AN, Rice DH, Ossoff RH, Sisson GA: Carcinoma of tongue in persons younger than 30 years of age. Arch Otolaryngol 1983; 109: 302-304. 27. Otto Sz: Cancer epidemiology in Hungary and the Béla Johan National Program for the Decade of Health. Path Oncol Res 2003; 9: 126-130. 28. Rich AM, Radden BG: Squamous cell carcinoma of the oral mucosa: a review of 244 cases in Australia. J Oral Pathol 1984; 13: 459-471. 29. Suba Zs, Barabás J, Szabó Gy, Takács D, Ujpál M: Increased prevalence of diabetes and obesity in patients with salivary gland tumors. Diabetes Care 2005; 28: 228. 30. Suba Zs, Barabás J: A szájüregi rák megelőzése. Medicina ZRT, Budapest, 2007. 31. Suba Zs: Gender-related hormonal risk factors for oral cancer. Pathol Oncol Res 2007; 13:195-202. 32. Suba Zs: Estrogen deficiency as cancer risk factor (Chapter V.). In Estrogen versus Cancer. Nova Science Publishers Inc, New York, in press, 2009. 33. Tsukuda M, Ooishi K, Mochimatsu I, Sato H: Head and neck carcinomas in patients under the age of forty years. Japanese J of Cancer Res 1993; 84: 748-752. 34. Ujpál M, Matos O, Bibok Gy, Somogyi A, Szabó Gy, Suba Zs: Diabetes and oral tumors in Hungary: Epidemiological correlations. Diabetes Care 2004; 27: 770-774. 35. Wu ShI, Chou P, Tsai ShT: The impact of years since menopause on the development of impaired glucose tolerance. J Clin Epidemiol 2001; 54: 117-120. Dr. Suba Zs, Dr. Mihályi Sz, Dr. Takács D, Dr. Gyulai-Gaál Sz: Oral cancer: Morbus Hungaricus in the XXI. c. Hungary is the leader both in oral cancer morbidity and mortality among the European countries. Oral cancer mortality had increased dramatically in Hungary to near fourfold between 1975 and 2002 both among the male and female populations. The increased oral cancer morbidity among the non-smoker, non-drinker elderly women and young adults, suggest that factors other than tobacco and alcohol consumption may also have important role in the pathogenesis of oral cancer. To reveal the epidemiological changes oral cancer cases and tumor-free controls were studied in the Department of Oral and Maxillofacial Surgery of the Semmelweis University in two phases between 1985-1986 and 2004-2005. In the 1 st phase of the study, 460 cases with histologically confirmed oral squamous cell cancer and 350 tumor-free control cases were included. In the 2nd phase data of 550 oral cancer cases and 450 tumor-free controls were examined. Location of the tumors, alcohol consumption, and smoking habits of the male and female patients were separately evaluated. Among the oral cancer cases and their controls the ratio of smokers showed a significantly decreasing tendency in the examined period. Both the male oral cancer patients and their controls showed a significant decrease in the ratio of regular drinkers, whereas among the female tumor cases and controls the ratio of alcohol consumers were similarly low in both phases. The high male to female ratio of oral cancer cases significantly decreased over the examined period. Among elderly women (>60 yrs) oral cancer morbidity conspicuously increased. Among male cases the primacy of lower lip cancer had been taken over by sublingual cancer during the examined period. Among female patients, gingival tumor location was the most frequent in both phases. Our data suggest that the extraordinarily rapid increase in oral cancer morbidity and mortality in Hungary is not reasonable simply on the basis of excessive tobacco and alcohol consumption habits. Changes in the male to female ratio of oral cancer after 20 years, the older age of female patients as compared with males and the gender related difference of the prevalent tumor sites suggest some role of gender specific, systemic risk factors for oral cancer. Key words: oral cancer, risk factors, smoking, alcohol consumption HÍRDETÉS Gyermekfogászati praxis a X. kerületben eladó 06-30-2220-916
