Fogorvosi szemle, 2007 (100. évfolyam, 1-6. szám)

2007-10-01 / 5. szám

FOGORVOSI SZEMLE ■ 100. évf. 5. sz. 2007.

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primarily leads to missing premolars [23]. Pax9 is also expressed in the maxillar and mandibular arches, and plays a role both in palate and tooth formation [24], In Pax9-deficient mice craniofacial anomalies, palate cleft

and a full lack of denture can also be observed [25]. In humans the mutation of the coding region of Pax9 gene [10] [26], [27], [11], [28], [29] or the deletion of Pax9 [28] primarily induce conditions with missing molars. The

C

IL-1 ß +3954 C/T

TLR-4 -299 G/A

H

TLR-4 -399 T/C

500 bp

JÔÔbp

^00 bp ^200 bp

J

PAX 9-912 C/T

^200 bp

Figure 3

Single nucleotide polymorphisms for eight different positions of six different genes potentially involved in the development of either periodontitis (A-H) or hypodontia (l-J).

The electrophoretic pictures show the PCR products, obtained from DNA of different individuals, following restriction enzyme digestion as specified in the text.

The name of the gene, the position, and the nucleotide variation is given in each picture heading. A DNA ladder is shown in each picture on the right side to facilitate fragment size estimation.