Fogorvosi szemle, 2004 (97. évfolyam, 1-6. szám)

2004-02-01 / 1. szám

27

FOGORVOSI SZEMLE ■ 97. évf. 1. sz. 2004.

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Velich N, Kovács K, Huszár T, Semjén G, Reiczigel J, Szabó Gy, Suba Zs:

The effect of platelet-rich plasma on new bone formation by augmentation with osseoconductive bone

substitute material in beagle dogs

Animal experiments were carried out with ostoconductive bone substitute ß-tricalcium phosphate (ß-TCP), with the aim of assessing the effect of the growth factors synthetised by platelets on the speed of ß-TCP incorporation and on the quality of newly formed bone. The question arises whether the results attained with this synthetic material approach are comparable to those attained with autologous bone. Defects in the mandibles of beagle dogs were filled with ß-TCP or with the mixture of ß-TCP and platelet rich plasma (PRP) obtained from autologous blood. The quality of the newly formed bone and the effect of PRP were studied by histologic and histomorphometric methods. On the 6th week, bone formation seemed to be more effective when PRP was applied in comparison with ß-TCP alone, but the difference was not significant. On the 12th week bone formation was significantly greater. The results demonstrate that the use of PRP accelerates the remodelling of the synthetic bone-substitute material ß-TCP.

Keywords: bone substitution, platelet-rich plasma, ß-TCP, remodelling, histomorphometry