Fogorvosi szemle, 2001 (94. évfolyam, 1-6. szám)

2001-02-01 / 1. szám

14

FOGORVOSI SZEMLE ■ 94. évf. 1. sz. 2001.

valókat, azzal jó támogatást nyújthat a gyógyszeres kezelésnek.

A lichenes betegek adatainak feldolgozása és a kezelési protokolok lehetőség szerinti bővítése tovább folyik a Semmelweis Egyetem Parodontológiai Klinikáján.

Irodalom:

1. Bernard R: Practical management of patients treated with alpha interferon. Acta Gastroenterol Belg 1997; 60: 211-213.

2. Biemann H, Reuterberg EV: Expression of fetal cytokératines in epidermal cells and colloid bodies. J Cutan Pathol 1998; 25: 35-43.

3. Carrozzo M, Gandolfo S: The management of oral lichen planus. Oral Dis 1999; 5: 196-205.

4. Djawari D: Die Wirkungen des Levamisole auf Lymphocyten und Granulocyten in Mucocutanischen Candidasis. Zeitschr Hautkr 1979; 54: 403-407.

5. Ebner H, Mischer P: Vitamine A acid in Lichen Planus. Acta Dermatovener (Stockholm) Suppl. 1975; 75.

6. Edwards JE, Lehner RI, Stiehm ER, Fischer TJ, Young LS: Severe Candida infections: clinical perspectives, immune defense mechanism and current concept of therapy. Ann Intern Med 1978; 89: 91-106.

7. Eversole LR: Immune pathogenesis of oral lichen planus and recurrent aphtous stomatiris. Semin Cutan Med Surg 1997; 16: 284-294.

8. Gonzalez-Moles MA, Gonzalez-Moles S, Ruiz-Avila I, Rodrigez-Avilla A, Bagan JV, Ceballes-Saloberna A: Detection de DNA papilloma virus humano en el liquen plano mediante hybriation in situ. Med Oral 1999; 4: 391-397.

9. Grynspan T, Diaz J, Abalatia J, Villapol L, Schneidermann J, Palese D, Bedrichesky R: Notre expériences sur le lichen ruber planus de la muquse buccale. Ann Dermatol Syphilligr 1966; 93: 531-537.

10. Haneke E: Levamisole Therapie unter verdinenen Dermatologische indicationes. Zeitschr Hautkr 1979; 54: 408-414.

11. Kövesi Gy, PÁLÓCZY K, OnÓdy K, Fekete B: Természetes human alpha interferon alkalmazása oralis virus fertőzésekben és következményes betegségekben. Lege Artis Medicinae 1993; 3: 1020-1027.

12. Laskaris G: Oral Diseases. Thieme Verlag. Suttgart-New-York. 1998; 98-107.

13. Lozada-Nur F, Miranda C: Oral liehen planus: topical and systemic therapy. Semin Cutan Med Surg: 1997; 16: 295-300.

14. Luderschmidt C: Therapy des nochmalige Herpes Simplex und Stomatitis mit Levamisole. Zeitschr Hautkr 1979; 54: 421^123.

15. Luderschmidt C, Wolf HH: Management of recurrent herpes simplex using levamisole. Hautartz: 1979; 30: 21-24.

16. Matthews JB, Scully CM, Potts AJC: Oral lichen planus: an immuno-peroxidase study using monoclonal antibody in human subject. BrJ Dermatol: 1983; 3: 587-592.

17. Minogna MD, Lo-Nuzio L, Favia G, Mignona RE, Carbone L, Bucci E: Oral lichen planus and hepatitis C. virus infection: a clinical evaluation of 263 cases. Int J Dermatol: 1998; 37: 575-578. 37.

18. Neumann R, Dutt CJ, Foster CS: Immunehistopathologic features and therapy of lichen planus. Am J Ophtalmol: 1993; 115: 494-499.

19. Olson RG, DuPlessis D, Barron C: Lichen planus dermatopathy: Demonstration of lichen planus specific epidermal antigen in affected patients. J Clin Lab Immunol: 1983; 10: 103-108.

20. Raab W: Specifische und unspecifische immune stimulazion in recidivirende herpes simplex. Zeitschr Hautkr. 1977; 52: 565-572.

21. Sallay K, Kövesi G, Döri F: Circulating immune complex study on patients with oral lichen planus. Oral Surg Oral Med Oral Path: 1989; 68: 567-570.

22. Schiffer M, Jones AM, Walker DM: Epithelial p53 gene expression and mutational activity combined with growth fraction assesment in oral lichen planus. J Oral Pathol Med: 1998; 27: 318-324.

23. Scully C, Beyli M, Ferreira MC, Ficarra G, Gill Y, Griffiths M. és mtsai: Update on oral lichen planus: ethiopathogenesis and management. Crit Rev Oral Biol Med: 1998; 9: 86-122.

24. Serpico R, Busicolano M, Femiano F: A statistical epidemiological study of a possible correlation between serum transaminaze levels and viral hepatic pathology markers in oral lichen planus. Minerva Stomatol: 1997; 46: 97-102.

25. Silverman SJr, Bahl S: Oral lichen planus: clinical characteristic, treatment, responses and malignant transformation. Am J Dent: 1997; 10: 259-263.

26. Smorgozewska E: Levamisol as an immunestimulating factor. Prbl Med Wieku Rozwoj: 1979; 8: 56-62.

27. Symones J: Immunepharmacologie des levamisole. Zeitschr Hautkr 1979; 54: 394-402.

28. Trnavska Z, Mikulikova D, Trnavsky K, Rovensky J: Effect of levamisole on in vitro collagene synthesis. Zeitschr Rheumatol: 1978; 37: 221-224.

29. Walton LJ, Thomhill MH, Macey MG, Farthing PM: Cutaneus lymphocyte associated antigen (CLA) and alpha-e-beta 7 integrins are expressed by mononuclear cells in skin and oral lichen planus. J Oral Pathol Med: 1997; 26: 402-407.

30. Walton LJ, Macey MG, Thornhill MH, Farthing PM: Intraepithelial subpopulation of T lymphocytes and Langerhans cells in oral lichen planus. J Oral Pathol Med: 1998; 27: 116-123.

31. Zhao ZZ, Savage NW, Walsh LJ: Association between mast cell and laminin in oral lichen planus. J Oral Pathol Med: 1998; 27:163-167.

Kövesi G.

Evaluation of clinical data and immunmodulant treatment of lichen oris patients

The number of patients with oral lichen planus increases all over the world. The treatment of this disease is not yet definitive. Although the etiology is not clear until now increasing number of data show relations between the environment and immune-responsiveness.

In this study the data (medical history and laboratory test results) of 33 lichen oris patients were processed. The prevalence of diabetes mellitus was much higher in lichen patients, than in persons without lichen oris. Likewise, higher transaminase serum levels in lichen patients were found, and there were two HCV positive cases among them. In contrast to the literary data instead of immune suppressive treatment the immune modulant treatment has been applied: 78% of ß levamisole treated and 90% of interferon alpha treated patients were cured. Only lichen patients without symptoms of general diseases could be stabilized.

Key words: oral lichen planus, diabetes mellitus, hepatitis C, ß-levamisol, interferon alpha