Szemészet, 1975 (112. évfolyam, 1-3. szám)

1975 / 3. szám

obtained by centrifugation. Mean urine amount was 500 ml after 30 minutes and 300 ml after 60 minutes.

Blood sugar levels did not show significant changes in the normal patients at this concentration of glycerol, whereas in the diabetics a slight decrease may be observed after 30 and 60 minutes from the start of the infusion (Table 2).

A mean increase of 25 mEq/L was found in natremia after 30 and 60 minutes. No significant changes were observed in kalemia.

Experimental

In Table 3 are illustrated the data obtained in twelve rabbits, given 2 g/Kg body weight of, respectively, 10% glycerol in saline (6 animals) and 10% glycerol+10% sodium ascorbate (6 animals), by microscopic examination of

0 30 60 90 120 Minutes

TIME AFTER ADMINISTRATION

Fig. 2. Mean effect of 0.8 g/Kg body weight of 10% Glycerol +10% Sodium Ascorbate on normal intraocular pressure in 7 patients submitted to cataract surgery. Infusion rate was 100 drops per minute. Maximum hypotensive effects were attained within 30 to 90 minutes from the start of the infusion. Mean serum osmolality levels are shown at the

different time intervals.

Table 2

Behaviour of intraocular pressure, serum osmolality and blood sugar levels following the intravenous infusion of 0.8 g/Kg body weight of 10% Glycerol in 10% Sodium Ascorbate (mean from 7 patiens)

No

Name

Surgical

intervention

Intraocular pressure

Serum osmolality

Blood sugar levels

test

after

30'

after

60'

after

90'

test

after 30'

©

©

©

a

after 90'

test

after 30'

after 60'

after 90'

H

H

W

hj

Й

H

1

B. A.

Cataract

16

16

14

14

12

12

—

—

320

797

397

358

0.75

0.94

0.83

1.15

2

F. F.

Cataract

18

14

12

10

10

8

13

12

299

937

876

594

0.95

0.74

0.86

1.08

3

C. L.

Cataract

16

14

12

10

11

10

12

11

300

442

466

310

1.00

1.05

0.89

1.08

4

R. L.

Cataract

20

22

16

18

16

19

—

—

302

363

348

306

1.31

1.18

1.24

1.29

5

V. P.

Cataract

14

17

9

8

10

9

—

—

290

459

385

320

0.65

0.80

0.82

0.75

6

M. A.

Cataract

18

17

18

15

12

8

12

10

304

700

330

306

1.78

1.51

1.83

1.89

7

G.T.

Cataract

—

12

—

10

—

8

—

—

299

397

312

300

0.90

1.00

0.92

0.90

170

0.8 g/Kg body weight intravenously 10 V. Glycerol + 10V. Sodium Ascorbate ( Mean from 7 patients }

(100 drops / minute)