Szemészet, 1975 (112. évfolyam, 1-3. szám)
1975 / 3. szám
these methods result in a higher glucose content, as the ascorbate, a highly reducing substance, is being also measured. Sodium and potassium were determined with the flame Photometer. Animal experiments A comparative investigation was carried out in twelve rabbits. They received 2 g/Kg body weight of, respectively 10% glycerol in saline and 10% glycerol + 10% sodium ascorbate intravenously. In all animals an indwelling vesical catheter was applied and urines were tested for the presence of blood at different time intervals. RESULTS Clinical The ocular hypotonizing effects of intravenous 10% glycerol + 10% sodium ascorbate were studied in 50 patienst submitted to surgical intervention for cataract (40 patients) and for glaucoma (10 patients) from the Ophthalmological Clinic of Rome University. Doses ranged from 0.6 to 1 g/Kg body weight. The rate of administration was 80 to 100 drops per minute. In all patients treated 10% glycerol + 10% sodium ascorbate caused marked reduction in intraocular pressure, attaining its maximum effect between 30 and 90 minutes from the start of the infusion. Table 1 illustrates the behaviour of intraocular pressure in 22 patients submitted to surgical intervention for cataract and glaucoma. Fig. 1 shows the response to 0.8 g/Kg body weight of 10% glycerol + 10% sodium ascorbate of a patient with hemorrhagic glaucoma of the right eye. Pretreatment pressure was 46 mm Hg and 90 minutes after the start of the infusion pressure was brought down to 22 mm Hg. Fig. 2 shows the effect of intravenous 10% glycerol + 10% sodium ascorbate on the intraocular pressure and on serum osmolality in 7 patienst submitted to surgical intervention for cataract after 30 to 60 minutes from the start of the Fig. 1. Effect of 0.8 g/Kg body weight of 10% Qlycerol-\-10% Sodium Ascorbate, administered intravenously, on hemorrhagic glaucoma. Infusion rate was 100 drops per minute. Maximum hypotensive effect was attained within 90 minutes from the start of the infusion. 168 0.8g/Kg body weight intravenously 10 V. Glicerol + 10 V. ^ Sodium Ascorbate in hemorrhagic glaucoma (100 drops / minute )
