Ardelean, Gavril - Buicu, Florin (szerk.): Satu Mare. Studii şi comunicări. Seria ştiinţele naturale 7. (2006)
Medicină
Satu Mare - Studii şi Comunicări Seria Ştiinţele Naturii Voi. VII (2006) de 18 bp, In vitro alela D a fost asociată cu creşterea expresiei genice. Această alelă contribuie la susceptibilitatea de nefropatie diabetică (81). Interesant, această asociere a fost şi mai puternică atunci când a fost analizată împreună cu polimorfisme ale genei aldozoreductazei sugerând o interacţiune genă-genă. O asociere slabă a fost găsită între gena HSD11B2, diabetul zaharat tip 1 şi BRD(82). Bibliografie 1. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD: The effect of angiotensin-convertingenzyme inhibition on diabetic nephropathy .The Collaborative Study Group. N Engl J Med 1993, 329: 1456-1462. 2. Bonnet F, Cooper ME, Kawachi H, Allen TJ, Boner G, Cao Z. Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertension. Diabetologia 2001; 44: 874-7. 3. Benigni A, Tomasoni S, Gagliardini E et al. Blocking angiotensin II synthesis/activity preserves glomerular nephrin in rats with severe nephrosis. J Am Soc Nephrol 2001; 12: 941-8. 4. Kelly DJ, Aaltonen P, Cox AJ et al. Expression of the slit-diaphragm protein, nephrin, in experimental diabetic nephropathy: differing effects of antiproteinuric therapies. Nephrol Dial Transplant 2002; 17:1327-32. 5. Langham RG, Kelly DJ, Cox AJ et al. Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition. Diabetologia 2002,45:1572-76 6. Tarnow L, Gluud C, Parving HH: Diabetic nephropathy and the insertion/deletion polymorphism of the angiotensin-converting enzyme gene. Nephrol Dial Transplant 1998,13:1125-1130 7. Fujisawa T, Ikegami H, Kawaguchi Y et al: Metaanalysis of association of insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy. Diabetologia 1998, 41: 47-53 8. Barnas U, Schmidt A, Illievich A et al.: Evaluation of risk factors for the development of nephropathy in patients with IDDM: insertion/deletion angiotensin converting enzyme gene polymorphism, hypertension and metabolic control. Diabetologia 1997, 40: 327-331 9. Hadjadj S, Belloum R, Bouhanick B et al.: Prognostic value of angio-tensin-I converting enzyme I/D polymorphism for nephropathy in type 1 diabetes mellitus: a prospective study. J Am Soc Nephrol 2001, 12: 541-549 10. Marre M, Bernadet P, Gallois Y et al.: Relationships between angiotensin I converting enzyme gene polymorphism, plasma levels and diabetic retinal and renal complications. Diabetes 1994, 43: 384-388 11. Doria A, Warrant JH, Krolewski AS: Genetic predisposition to diabetic nephropathy. Evidence for a role of the angiotensin I-converting enzyme gene. Diabetes 1994, 43: 690-695 12. Azar ST, Zalloua PA, Medlej R, Halabi G: The DD genotype of the ACE gene polymorphism is associated with diabetic nephropathy in the type-1 diabetics. Endocr Res 2001,27: 99-108 13. de Azevedo MJ, Dalmaz CA, Caramori ML et al.: ACE and PC-1 gene polymorphisms in normoalbuminuric Type 1 diabetic patients: a 10-year prospective study. J Diabetes Complications 2002, 16:255-262 14. Jacobsen P, Rossing K, Rossing P et al.: Angiotensin converting enzyme gene polymorphism and ACE inhibition in diabetic nephropathy. Kidney Int 1998, 53:1002-1006 15. Parving HH, Jacobsen P, Tamow L et al.: Effect of deletion polymorphism of angiotensin converting enzyme gene on progression of diabetic nephropathy during inhibition of angiotensin converting enzyme: observational follow up study. Bmj 1996, 313: 591-59 16. Penno G, Chaturvedi N, Talmud PJ et al.: Effect of angiotensin-converting enzyme (ACE)gene polymorphism on progression of renal disease and the influence of ACE inhibition in IDDM patients:findings from the EUCLID Randomized Controlled Trial. EURODIAB Controlled Trial of Lisinopril in IDDM. Diabetes 1998, 47: 1507-1511 17. Rudberg S, Rasmussen LM, Bangstad HJ, Osterby R: Influence of insertion/deletion polymorphism in the ACE-I gene on the progression of diabetic glomerulopathy in type 1 diabetic patients with microalbuminuria. Diabetes Care 2000, 23: 544-548 159
