203255. lajstromszámú szabadalom • Eljárás hibrid interferonok előállítására
HU 203 255 B a.5: C 12 N 15/21 2. ábra: A LyIFN-a-2 és a LyIFN-a-3 kódoló szakaszainak nukleotid szekvenciája (a kódoló tripletek számozottak). a-2 .,. GAGACAATAACCCTGATAAATGCTTCAATAATATTGAAAAAGGAAGAOTAATG tt«l ... GAGACAATAACCCTGAIAAATCCTTCAATAAIATTGAAAAACCAACACTAAIQ 1 S«u3A 16 0*2 TGT GAT CTG CCT CAG ACT CAC AGC CTG GGT AAC AGG AGG GCC TTG ATA 0-3 TGT GAT CTC CCT GAG ACC CAC AGC CTG GAT AAC AGG AGG ACC TTG ATG 32 0-2 CTC CTG GCA CAA ATG CGA AGA ATC TCT CCT ITC TCC TGC CTG AAG GAC 0-3 CTC CTG GCA CAA ATG AGC AGA ATC TCT CCT TCC TCC TGT CTG ATG GAC 48 0-2 AGA CAT GAC ITT GAA TTC CCC CAG GAG GAG TTT GAT GAT AAA CAG TTC 0-3 AGA CAT GAC TTT GGA TTT CCC CAG GAG GAG TTT GAT GGC AAC CAG TTC S«u3A 64 o-2 CAG AAG GCT CAA GCC ATC TCT GTC CTC CAT GAG ATG ATC CAG- CAG ACC o-3 CAG AAG GCT CCA GCC ATC TCT GTC CTC CAT GAG CTG ATC CAG CAG ATC 80 o-2 TTC AAC CTC TTC AGC ACA AAG GAC ICA TCT GCT GCT TTG GAT GAG ACC o-3 TTC AAC CTC TTT ACC ACA AAA GAT TCA TCT GCT GCT TGG GAT GAG GAC PvuII 96 a-2 CTT CTA GAT GAA TTC TAC ATC GAA CTT GAC CAG CAG CTG AAT GAC CTG o-3 CTC CTA GAC AAA TTC TGC ACC GAA CTC TAC CAG CAG CTG AAT GAC TTG 112 a-2 GAG TCC TGT GTG ATG CAG GAA GIG GGG GTG ATA GAG TCT CCC CTG ATG a-3 GAA GCC TGT GTG ATG CAG GAG GAG AGG GTG GGA GAA ACT CCC CTG ATG 128 a-2 TAC GAG GAC TCC ATC CTG GCT GTG AGG AAA TAC TTC CAA AGA ATC ACT a-3 AAT GCG GAC TCC ATC TTG GCT GTG AAG AAA TAC TTC CGA AGA ATC ACT 144 a-2 CTA TAT CTG ACA GAG AAG AAA TAC AGC TCT TGT GCC TGG GAG GTT GTC 0-3 CTC TAT CTG ACA GAG AAG AAA TAC AGC CCT TGT GCC TGG GAG GTT GTC Sau3A 160 a-2 AGA GCA GAA ATC ATG AGA TCC TTC TCT TTA TCA ATC AAC TTG CAA AAA a-3 AGA GCA GAA ATC ATG AGA TCC CTC TCT TTA TCA ACA AAC TTG CAA GAA 166 a-2 AGA TTG AAG ACT AAG GAA TGA GACCTGGTACAACACGGAAATGATTCTTATAGACT a-3 AGA TTA AGG AGG AAG GAA TAA CACCTGGTCCAACATGAAACAATTCTTATTGACTC a-2 AATACAGCAGCTCACACTTCGACAAGTTGIGCTCTTTCAAAGACCCTTGTTTCTGCCAAAACC a-3 ATATACCAGGTCACGCTTTCATGAATTCTGCCATTTCAAAGACTCTCACTTCTGCTATAACTA a-2 ATGCTATGTTTTGAAICAAATGTGTCAAGTGTTTTCAGGAGTGTTAAGCAACATCCTGTT a-3 TGACCATGCTGATAAACTGATTTATCTATTTAAATATTTATTTAGCTATTCATAAGATTT PvuII S«u3A a-2 CAGCTGTATGGGCACTAGTCCCTTACAGATGACCATGCTGATGGATCTATTCATCTATTTATT a-3 AAATTATTTTTGTTCATATAACATCATGTGCATCTTTACACTGTGGTTAGTGTAATAAAACAT a-2 TAAATCTTTATTTAGTTAACTATCTATAGGGCTTAAATTAGTTTTOTTCATATTATATTATGT a-3 GTTCCTTAIATTTACTCAAATTCATTATTTT.... 0-2 GAACTTTTACATTCTGAATTGTGTAACAAAAACATGTTCTTTATAITTATTATTTTGCCTTGT 0-2 TTATTAAAITTTTACTATAG... 30
