200795. lajstromszámú szabadalom • Eljárás többszörös horgokat tartalmazó plazminogén aktivátorok előállítására
HU 200795 B Int Cl5 C 12 N 15/58 A 61 K 37/54 Az l.c ábra szerinti hármas-horog PA 1 11 21 31 41 51 GGATCCAGCAATCATGGATGCAATGAAGAGAGGGCTCTGCTGTGTGCTGCTGCTGTGTGG tPA szignál peptid, MetAspAlaMetLysArgGlyLeuCysCysValleuLeuleuCysGly 35: aminosav 61 71 81 91 101 111 AGCAGT CTTCGT T T CGCCCAGCCAGGAAATCCAT GCCCGAT TCAGAAGAGGAGCCAGATC AlaValPheVal5erPro5erGlnGluIleHisAlaArgPheArgArgGlyAlaArgper 121 131 141 151 161 171 TTACCAAGTGATCTGCAGAGATGAAAAAACGCAGATGATATACCAGCAACATCAGTCATG TyrGlnValIleCysArgAspGluLysThrGlnMetlleTyrGlnGlnHisGlnSerTrp IBI 191 201 211 221 231 GCTGCGCCCTGTGCTCAGAAGCAACCGGGTGGAATATTGCTGGTGCAACAGTGGCAGGGC LeuArgProValLeuArgSerAsnArgValgluTyrCysTrpCysAsnSerGlyArgAla 241 251 261 271 281 291 ACAGTGCCACTCAGTGCCTGTCAAAAGTTGCAGCGAGCCAAGGTGTTTCAACGGGGGCAC GlnCysHisSerValProValLysSerCysSerGluProArgCysPheAsnGlyGlyThr 301 311 321 331 341 351 CTGCCAGCAGGCCCTGTACTTCTCAGATTTCGTGTGCCAGTGCCCCGAAGGATTTGCTGG CysGlnGlnAlaLeuTyrPheSerAspPheValCysGlnCysProGluGlyPheAlaGly 361 371 381 391 401 411 GAAGT GCTGTGAAAT AGAT ACCAGGGCCACGT GCT ACGAGGACCAGGGCATCAGCT ACAG LysCysCysGluIleAspThrArgAlaThrCysT yrGluAspGlnGlylleSerT yrArg 421 431 441 451 461 471 GGGCACGTGGAGCACAGCGGAGAGTGGCGCCGAGTGCACCAACTGGAACAGCAGCGCGTT GlyThrTrpSerThrAlaGluSerGlyAlaGluCysThrAsnTrpAsnSerSerAlaLeu 481 491 501 511 521 531 GGCCCAGAAGCCCTACAGCGGGCGGAGGCCAGACGCCATCAGGCTGGGCCTGGGGAACCA AlaGlnLysProTyrSerGlyArgArgProAspAlalleArgLeuGlyLeuGlyAsnHis 541 551 561 571 581 591 CAACTACTGCAGAAACCCAGATCGAGACTCAAAGCCCTGGTGCTACGTCTTTAAGGCGGG AsnTyrCysArgAsnProAspArgAspSerLysProTrpCysTyrValPhelysAlaGly 601 611 621 631 641 651 GAAGT ACAGCT CAGAGTTCT GCAGCACCCCT GCCT GCT CT GAGGGAAACAGT GACT GCTA LysTyrSerSerC-luPheCysSerThrProAlaCysSerGluGlyAsnSerAspCysTyr 661 671 681 691 701 711 CTTT GGGAAT GGGTCAGCCT ACCGT GGCACGCACAGCCT CACCGAGT CGGGT GCCT CCT G PheGlyAsnGlySerAlaTyrArgGlyThrHisSerLeuThrGluSerGlyAlaSerCys 721 731 741 751 761 771 CCTCCCGTGGAATTCCATGATCCTGATAGGCAAGGTTTACACAGCACAGAACCCCAGTGC LeuProTrpAsnSerMetlleLeuIleGlyLysValTyrThrAlaGlnAsnProSerAla 781 791 801 811 821 831 CCAGGCACTGGGCCT GGGCAAACAT AATT ACT GCCGGAAT CCTGAT GGGGAT GCCAAGCC GlnAlaLeuGlyLeuGlyLysHisAsnTyrCysArgAsnProAspGlyAspAlaLysPro 841 851 861 871 881 891 CTGGTGCCACGTGCTGAAGAACCGCAGGCTGACGTGGGAGTACTGTGATGTGCCCTCCTG TrpCysHisValleulysAsnArgArgLeuThrTrpGluTyrCysAspValProSerCys 11. ábra
