200695. lajstromszámú szabadalom • Eljárás szöveti plazminogén aktivátort tartalmazó stabil gyógyszerkészítmények elöállítására

Int

J200695B

: A 61K 37/48

SerTyr Gin Val Ile Cys Arg Asp Glu Lys Thr Gin Met Ile Tyr Gin"Gin His Gin 5er 1

Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu Tyr Cys Trp Cys Asn Ser Gly

Arg Ala Gin Cys His Ser Val Pro Val Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn

50

Gly Gly Thr Cys Gin Gin Ala Leu Tyr Phe Ser Asp Phe Val Cys Gin Cys Pro Glu

Gly Phe Ala Gly Lys Cya Cys Glu Ue Asp Thr Arg Ala Thr Cys Tyr Glu Asp Gin

Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu Cys Thr Asn Trp 100

Asn Ser Ser Ala Leu. Ala Gin Lys Pro Tyr Ser Gly Arg Arg Pro Asp Ala Ile Arg

Leu Gly Leu Gly Asn His Asn Tyr Cys Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp

150

Cys Tyr Val Phe Lys Ala Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys

Ser Glu Gly Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His

Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ue Leu Ile Gly Lys

200

Val Tyr Thr Ala Gin Asn Pro Ser Ala Gin Ala Leu Gly Leu Gly Lys His Aan Tyr

Cys Arg Asn Pro Asp Gly Asp Ala Lys Pro Trp Cys His Met Leu Lys Asn Arg Arg

250

Leu Thr Trp Glu Tyr Cys Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gin Tyr

Ser Gin Pro Gin Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro Trp

Gin Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg Phe Leu Cys Gly

300

Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala Ala His Cys Phe Gin Glu Arg Phe

Pro Pro His His Leu Thr Val Ile Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu

Glu Gin Lys Phe Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr 350

Tyr Asp Asn Asp Ile Ala Leu Leu Gin Leu Lys Ser Asp Ser Ser Arg Cys Ala Gin

Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp Leu Gin Leu Pro Asp

400

Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys His Glu Ala Leu Ser Pro Phe Tyr

Ser Glu Arg Leu Lys Glu Ala His Vai Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser

Gin His Leu Leu Asn Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg

450

Ser Gly Gly Pro Gin Ala Asn Leu His Asp Ala Cys Gin Gly Asp Ser Gly Gly Pro

Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile Ser Trp Gly Leu

500

Gly Cys Gly Gin Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp

Trp Ile Arg Asp Asn Met Arg Pro

527

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