199803. lajstromszámú szabadalom • Eljárás 1-acil-2,3-dihidro-4(1H)-kinolin-4-oxim-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására

1

HU 199803 B

2

Pl.

R1 R6

IR(KBr,cm'*)

NMR(CDCl3, ppm)

Op.

sz.

co

106

^>C1 -CH3

1680,1650,

2,22(3H,s),2,82(2H,t),

141,4-1465,1380

4,18(2H,s),

145,0

Cl

6,91-7,89(6H,m)

107-Oa 1

1690,1645,

2,82(2H,t),

186,3-1475,1380

4,12(2H,t),

187,9

Cl

7,20-7,70(6H,m)

108

^ -Cp3

1790,1640,

2,90(2H,t),

136,2--/>C1

1335,1175

4,20(2H,t),

140,2

7,18-8,ll(6H,m)

Cl

109

/=% -COCH3

1695,1640,

2,45(3H,s),

135,9-1420,1370

2,90(2H,t),

4,25(2H,t),

139,9

Cl

7,19-8,ll(6H,m)

110

^ -0CH3

1680,1650,

2,83(2H,t),

99,6--^>a

1460,1380

3,65(3H,s),

4,21(2H,t),

101,3

Cl

6,61-7,98(6H,m)

111

_ -N(CH3)2

1670,1640,

2,80(2H,t),

177,7--ç>°

1460,1365

2,87(6H,s),

4,24(2H,t),

179,7

Cl

6,38-7,92(6H,m)

112

S-T. -COOCH3 ^>C1

1720,1615,

2,80(2H,t),

174,9-1480,1390

3,75(3H,s),

4,22(2H,t),

177,0

Cl

7,16-7,98(6H,m)

113

0 F

1695,1645,

2,82(2H,t),

106,8-1480,1360

4,25(2H,t),

6,67-8,09(8H,m)

109,0

114-SCH3

1680,1640,

2,23(3H,s),

113,2

1470,1385

2,82(2H,t),

4,14(2H,t),

117,2

Cl

6,91 -7,9 l(6H,m)

115

_ -S02CH3

1660,1380,

[DMSO-d6+CDCl3]

191,6-1220,1155

2,96(2H,t),3,02(3H,s),

4,19(2H,t),

195,6

Cl

7,36-8,16(6H,m)

116

_ -SOCH3

1660,1385,

2,55(3H,s),

183,3--Q“

1240,1055

2,91 (2H,t), 4,01 (2H,t),

186,8

Cl

7,33-8,16(6H,m)

117

0 F

1660,1595,

2,34(3H,s)

93,5-1480,1360

2,77(2H,t),

96,3

H3

C

4,12 (2H,t), 6,73-8,04(7H,m)

118

/=\ -NO2 ^l_tci

1700,1660,

2,77(2H,t),

180,9-1475,1340

4,02(2H,t),

183,1

Cl

7,04-7,79(6H,m)

119

y=\ -0CH3

1680,1635,

2,27(3H,s),2,76(2H,t),

112,2-1485,1370

3,54(3H,s),4,25(2H,t),

116,0

h3

c

6,60-8,0 l(7H,m)

120

y=\ -OCH3

~\J

1680,1640,

2,81(2H,t),

167,2-1440,1365

3,50(3H,s),4,32(2H,t)

6,33-8,02(8H,m)

168,4

121

O Br

1690,1640,

2,84(2H,t),

153,0-1470,1370

4,28(2H,t),

7,21-7,89(8H,m)

156,7

122-O Br

1695,1640,

2,33(3H,s),

111,7-1445.1370

2,78(2H,t),

116,2

H3

C

4,13(2H,t),

6,98-7,92(7H,m)

15