199803. lajstromszámú szabadalom • Eljárás 1-acil-2,3-dihidro-4(1H)-kinolin-4-oxim-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására

1

HU 199803 B

2

Pl.

R1

IR(KBr,cm-‘)

NMR(CDCb, ppm)

Op.

sz.

(*C)

70-o

1695,1640,

2,78(2H,t),3,49(3H,s),

102,3-1460,1360

4,31(2H,t),

107,3

h3

co

6,63-7,9 l(7H,m)

71

O

1690,1640,

2,80(2H,t),

121,8-1480,1370

4,20(2H,t),

122,5

F

6,83-7,94(7H,m)

72

1700,1665,

2,87(2H,t),

114,1-1380,1190

4,14(2H,t),

120,3

Br

7,04-7,96(7H,m)

73

o

1700,1660,

[DMSO-dó]

176,2-1570,1385

2,88(2H,t),3,99(2H,t),

176,5

02N

7,17-8,22(7H,m)

74

N02

1690,1655,

2,80(2H,t),

179,6-1395,1345

4,07(2H,t),

181,3

Cl

7,07-8,33(6H,m)

75-Ç)-c(cm3

1695,1645,

1,31 (9H,s),2,81 (2H,t),

124,5-1455,1345

4,21(2H, t),6,99-7,95 (7H,m)

127,6

76

1690,1650,

2,3 l(2H,s),2,78(2H,0,

156,1-1370,900

4,09(2H,0,7,02-7,93

160,2

CH3

(6H,m)

77

O

1690,1635,

2,84(2H,0,

141,7-1475,1370

4,25(2H,t),

7,04-7,96(8H,m)

143,6

78

~Ç}~ ch3 C1

1690,1660,

2,36(3H,s),2,81(2H,0,

157,8-1465,1370

4,09(2H,0

7,02-7,89(6H,m)

158,3

79

co

1695,1660,

2,71(2H,0,

43,2-1460,1360

4,00(2H,0,

47,5

80

TO-O

1680,1640,

1460,1360

7,01-7,91(10H,m)

2,85(2H,0,

4,28(2H,0,

7,00-8,01(10H,m)

134,0-136,5

81

1690,1650,

2,70(2H,0,

129,4-1460,1370

3,96(2H,0,

131,8

i

6,95-7,9 l(7H,m)

82

TO

1690,1640,

2,82(2H,0,3,81(3H,s),

138,6-1460,1355

4,27(2H,t),

140,0

0CH

3

6,95-8,02(7H,m)

83

1690,1635,

[DMSO-dö+CDCb]

/-N

1470,1360

2,90(2H,0,4,21 (2H,0,

175,8-7,26-7,58(3H,m),7,90-8,09

(2H,m),8,70-8,86(2H,m)

177,8

84

1680,1650,

[DMSO-dó]

148,0-N^\

“O

1465,1380

2,86(2H,0,4,20(2H,t), 7,23-7,62(3H,m),7,72-8,12 (3H,m),8,55-8,60( 1 H,m)

149,8

85

TO

1685,1640,

[DMSO-dő]

171,7-1490,1400

2,93(2H,0,4,10(2H,0, 7,35-8,01(2H,m),8,07- 8,25(2H,m),8,60-8,82 ( 1 H,m),8,94-9,02(2H,m)

179,2

86

1690,1640,

2,92(2H,t),4,35(2H,0,

149,8-N —.

1480,1375

7,15-7,36(2H,m),8,01

151,0

(lH,d),8,47-8,54(lH,m),

N

8,77(lH,d), 9,08-9,12(lH,m)

87

jn

1690,1635,

2,87(2H,t),

94,1-1415,1365

4,36(2H,t),

96,1

6,98-8,03(6H,m)

13