199159. lajstromszámú szabadalom • Eljárás véralvadásgátló peptidek és ezeket hatóanyagként tartalmazó gyógyszerkészítmények előállítására

13

199159

58. példa

Ac-Thr-Pro-Lys-Pro-Gln-Ser-His-Asn-Asp - Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr- -Leu-Gln-OH

59. példa ®

Ac-Thr-Pro-Asn-Pro-Glu-Ser-His-Asn-Asn - -Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr- -Leu-Gln-OH

60. példa 10

Suc-Tyr-Glu-Pro-Ile-Pro-Glu-Ala-Cha-Asn-61. példa

S(3|C IJh G|U Pr° lle Pr° GIU G1U Tyr Cha’ 15

62. példa

Suc-Tyr-Glu-Pro-Ile-Pro-Glu-Glu-Pro-Cha-D-Glu-OH

20

63. példa

Suc-Tha-Glu-Pro-Ile-Pro-Glu-Glu-Pro-Cha-D-Glu-OH

64. példa

Suc-Npa-Glu-Pro-Ile-Pro-Glu-Glu-Ala-Cha-D-Glu-OH

65. példa

Suc-Tyr-Glu-Pro-Ile-Pro-Glu-GIu-Ala-Cha-D-Glu-OH

66. példa

Mal-Tyr-Glu-Pro-Ile-Pro-Glu-Glu-Ala-Cha-D-Glu-OH

67. példa

Glt-Tyr-Glu-Pro-Ile-Pro-Glu-Glu-Ala-Cha-D-Glu-OH

68. példa

Fum-Tyr-Glu-Pro-IIe-Pro-Glu-Glu-Ala-Cha-P-Glu-OH

14

, Aminósav analízis (6n HCl hidrolízis; 24-ó; 106°C-on

Pslda

száma

His

Asx

Ser

Glx

Pro

Ala

Gly

Ile

Leu

Tyr

Phe

2

0.95(1)

3.12(3)

0.88(1)

5.15(5)

1.1KD

103(1)

0.95(1)

1.00(1)

0.84(1)

0.99(1)

3

3.03(3)

5.02(5)

1-03(1)

1.01(1)

0.97(1)

1.02(1)

0.93(1)

0.99(1)

4

1.02(1)

5.04(5)

1.01(1)

0.98(1)

1.03(1)

0.89(1)

103(1.)

5

5.05(5)

1.04(1)

0.97(1)

1.01(1)

0.93(1)

0.99(1)

6

0.94(1)

4.48(4)

0.94(1)

0.88(1)

0.94(1)

0.98(1)

0.89(1)

0.95(1)

7

0.94(1)

4.46(4)

0.96(1)

0.89(1)

0.92(1)

0.98(1)

0.87(1)

0.98(1)

8

1-03(1)

4.00(4)

1.08(1)

1.02(1)

0.99(1)

1.01(1)

0.88(1)

0 99(1)

9

1.03(1)

4.83(5)

1.08(1)

1.01(1)

0.99(1)

1.04(1)

1.01(1)

10

1.03(1)

5.02(5)

1.00(1)

0.96(1)

101(1)

0.94(1)

1 03(1)

11

0.99(1)

5.02(5)

0.98(1)

0.98(1)

0.98(1)

1.03(1)

1.02(1)

1.00(1)

12

5.10(5)

1.01(1)

0.92(1)

103(1)

0.91(1)

1.02(1)

13

1.04(1)

3.93(4)

1.11(1)

0.95(1)

1.03(1)

0.90(1)

1.02(1)

14

0.99(1)

5.09(5)

1.00(1)

0.99(1)

1.00(1)

0.97(1)

1.89(2)

15

0.60(1)

4.87(5)

1-14(1).

1.04(1)

0.97(1)

1.02(1)

0.94(1)

16

1.10(1)

4.97(5)

1.07(1)

0.99(1)

0.94(1)

105(1)

0.88(1)

17

0.41(1)

5.03(5)

0.99(1)

1.00(1)

0.96(1)

102(1)

0.99(1)

18

1.01(1)

4.99(5)

1.00(1)

1.02(1)

1.03(1)

0.90(1)

1.05(1)

19

1.03(1)

4.95(5)

0.98(1)

1-03(1)

1.03(1)

1.02(1)

0.92(1)

1.03(1)

20

1.07(1)

4.94(5)

1.02(1)

1.01(1)

102(1)

0.93(1)

103(1)

21

1 09(1)

4.96(5)

1.08(1)

0.96(1)

0.94(1)

0 89(1)

1 09(1)

22

2 42(3)

3 07(3)

2.24(2)

1.05(1)

1.06(1)

101(1)

1.09(1).

8