198086. lajstromszámú szabadalom • Eljárás immunstimuláns acil-tripeptídek előállítására

198 086

PFIZER INC.

Nemzetközi osztályozás: C 07 K 5/02;

A 61 K 37/02

D

h2nchcooh

(ch2)2

COOH (9 )

1. R - COCl

NMM-------------------------------------;>

pH “ 9,0

2. C6H5CH2Br

3. HOSuc.CMEC

D

D.

R-CONHCHCOOBz

l

(CH-^), 0

i "■

CO-O -N

rf

(10) °

(8)-> R-CONHCHCOOBz

(ch2)2

D

1. HOSuCjDCC

CONHCHCOOH--------------7“7^

lL 2.alfa-Z lizin

(CH2)3 BSA

ZHNCHCONHNHZ (11) D

R-CONHCHCOOBz

(CH2)2

CONHCHCONH L

1. H2 10°/oPd c

ZNa ÄTpH = 1,0 NHZ

(CfT^ D (CH2)4-CH-COOH

ZHNCHCONHNHZ (12) D D

R-CONHCHCOOH

(CH,)

NH

2

2

>

CONHCHCONH -(CHo),-CH-COOH | L

HoNCHCOOH (13)

1 n ■