198003. lajstromszámú szabadalom • Eljárás heterociklusos csoporttal vagy fenil csoporttal helyettesített karboxi-alkénsav származékok előállítására
1 2 198 003 19 BOC (transz) 20 BOC (cisz) 21 Cbz 22 Cbz Me Me Me Me Me Me Et Et 3415, 1720, 1541, 1155 (CHd3) 3410,1720,1541, 1150 (CHCL3) 3390, 1720, 1540, (CHCI3) 3395,1720 (CHCI3) 1,52 (s, 9H), 3,54 (d, J*>,5Hz, 2H), 3,64 (s, 3H), 3,76 (s, 3H), 7,11 (s, 1H), 7,18(t,J-6,5Hz, 1H), 9,12 (brs, 1H) /CDCI3/ 1,51 (s, 9H), 3,54 (d, J^.SHz, 2H), 3,69 ?s,3H), 3,83 (s,3H), 7.03 (s, 1H), 7,08 (t, J»6,5Hz, 1H), 9,12 (brs. 1H) |CD Cl3/ / 3,41,3,48 (2xd, J-8Hz, 2H), 3,65 3,73, 3,69, 3,83 (4xs,6H), 5,24 (s, 2H), 7,00- 7,37 (m, 7H) /cöa3/ 1,19,1,20,1,22, l,30(4xt,J-8Hz,6H), 3,34, 3,42 (2xd, J-8Hz, 2H), 4,08, 4,12, 4.15.4.24 (4xq, J«8Hz, 4H), 5,21,5,22, 5.24 (3xs, 2H), 7,03, 7,13 (2xt, J-8Hz, 1H), 7,03 (s, 1H), 7,31 (s, fill), 10,15 (brs. 1H) ÍCDCI3/ 23 Cbz 24 Cbz 25 Cbz 26 HCO (transz) 27 H(*:0 (dsz) 28 H^O (cisz)' 29 HÍo (transz) 30 acH2io (transz) Bzl Bzl 3400, 1725 (CHCI3) PMB Bzl BH Bzl 3490,1725 (CDCI3) Me Me 3380,3140,1722, 1705,1695 (CHd3) 100°C Me Me 3390,3150,1715 1700,1535 (CHCI3) Me t-Bu 3380,1710,1540, (CHOU) op. 103 —104°C Me t-Bu Me Me 3,31,3,42 (2xd, J-7Hz, 211), 5,01 5,03,5,11,5,17 (4xs, 6H), 6,96-7,30 (m,17H), 10,19 (brs. 1H) /cdq3/ 3,40 (d, J»7Hz, 2H), 3,75 (s, 3H), 5,10 (s, 2H), 5,15 (s, 2H), 5,20 (s, 2H), 6,8-7,4 (m, 16H) /CDCI3/ 3,34, 3,40 (2xd, J-7Hz, 2H), 5,02, 5,05, 5,09, 5,17 (4xs, 4H), 6,8-7,4 (m, 23H), 9,90 (brs. 1H) /CDCI3/ 3,46(d, J-7,5Hz, 2H), 3,66 (s, 3H), 3.78 (s,3H), 7,05 (s,lH), 7,24 (t, J»7,5Hz, 1H), 8,49 (s, 1H) ;cdci3/ 3,56 (d, J.7 Hz, 2H), 3,73 (s, 3H), 3,84 (s, 3H), 7,02 (t, J«7Hz, 1H), 7.12 (s, 1H), 8,55 (s, 1H) /CDCI3/ 1,47 (s, 9H), 3,50 (d, J-7Hz, 2H), 3,86 (s, 3H), 7,07 (t^*7Hz, lH), 7.13 (s, 1H), 8,60 (s, }H) |CDa3/ 1,44 (s, 9H), 3,27 (d, J-7Hz, 2H), 3,80 (s, 3H), 7,05 (s, 1H), 7,31 (t, J«7Hz, 1H), 8,52 (s, 1H) /CDCI3/ 3,50 (d, J^,5Hz, 2H), 3,68 (s, 3H), 3.79 (s, 3H), 4,25 (s, 2H), 7,24 (s, 1H), 7,24 (t, J«6,5Hz, 1H) /CDQ3/ 9
