196846. lajstromszámú szabadalom • Eljárás a humán gamma-interferon biológiailag aktív származékainak és az ezeket tartalmazó gyógyszerkészítmények előllítására
1 2 196.846 (II) DNS-szekvenda IFNI: la Met Cys Tyr Cys Gin Asp 5’ AA XTC ATG TGC ÍAC TGC CAG GAC 3’ G TAC ACG ATG ACG GTC CTG Eco RI ----------------------------- lb----------------*---------------------------Ic-----------------------Pro Tyr Val Lys Glu Ale CCG TAC GTT AAA GAA GCT Glu Asn GAA AAC Leu Lys CTG AAA GGC ATG CAA TTT CTT-------Ic — Lys Tyr AAA TAC TTT ATG -----If----CGA CTT TTG GAC TTT----------_Id-------------------■»---------------Ig----Phe Asn Ala TTC AAC GCT AAG TTG CGA CCA GTA--------------------------------Gly His Ser Asp Val GCT CAT TCT GAC GTT AGA CTG CAA —Ih------Ala Asp GCT GAC CGA CTG TTA CCA Ii--------•> Asn Gly Thr Leu Phe Leu (Gly) AAT GGT ACT CTG TTC CTG GG TGA GAC AAG GAC CCC TAG Ij Bam Hi * (II) DNS-szekvencia IFN-II: Ila (Gly) Ile Leu Lys Asn Trp G ATC CTG AAA AAC TGG Bam HI GAC TTT TTG ACC Glu Glu Ser Asp GAAGAATCT GAC Arg CGT Lys lie Met .Gin Ser Gin AAA ATC ATG CAA TCT CAG TTtItAG TAC GTT AGA GTC Tyr Phe Lys Leu Phe TAC TTC ÄAA.CTG TTC TTT ATG AAG ------------* Lys AAA GAC AAG TTT Lys AAA TTT CTT CTT AGA CTG CCA Hb -------------------------------------lie---------------------M He ATC TAG Ildiié— Asn AAC TTG Val Ser Phe GTT TCT TTC CAA AGA AAG Phe Lys Asp TTT AAA GAC AAA TTT CTG Ilf—--------------Asp Gin Ser He Gin Lys GAC CAG TCT ATC CAG AAA CTG GTC I AGA TAG GTC TTT Hg-Ser TCT AGA Lys Glu Asp Met Asn AAG GAA GAC ATG AAC TAG TTC CTTlCTG TAC TTG------------------“—►U—;----------------Ill-Val GTT CAA Val Glu Thr GTT GAA ACT CAA CTT TGA Hh----------------Lys Phe Phe AAA TTT TTC TTT AAA AAG Hj------------------6
