196457. lajstromszámú szabadalom • Eljárás interferonok előállítására
LelF A Le IF 3 LelF C Le IF 0 Le IF E Le IF F Le IF G Le IF H LelF A Le IF 3 LelF C Le IF 0 LelF £ LelF F LelF G LelF H LelF A Leír 3 LelF C LelF 0 Leír E LelF F LelF G LelF H Leír A LelF 3 LelF G L-IF D Lair E LelF F LelF G LelF H LelF A LelF 3 LelF C LelF 0 LelF 2 LelF F LelF G LelF H LelF A Lel? 3 LelF C LelF 0 LelF E LelF F LelF C LelF H Le IF A LelF B LelF C LelF D LelF 2 LelF F LelF G LelF H LelF A LelF B LeíF C LelF D LelF E LelF F Leír G LelF H LelF A LelF 3 LelF 0 LelF 0 LelF E LelF F LelF G LelF H LelF A LelF S LelF C LelF E LelF F LelF G LelF H LelF 3 LelF F 196457 Nemzetközi osztályozás: c c 12 N 12 P 15/00 21/00 60-40-20 >1 20 40 TCAGCCTAAACCTTAGGCTCACCCATTTCAACCAGTCTAGCACCATCTGCAACATCTACAATGGCCTTGACCTTTGCTTTACTGGTCGCCCTCCTGGTGC tactagctcagcaccatccgcaacatctacaatcgccttcactttttahtaatcgtcgccctagtggtgc CAACGTTATCCATCTCAACTACCCTACCAATATTTGCAACATCCCAArCGCCCTGTCCTTHCTTTACTTATCGCCCTGCTGCTGC CAACCTTCACAGTCACCCATCTCAGCAACCCCAGAAGTATCTGCAA rATCTACCATCCCCTCGCCCTTTCCTTTACTCArCGTCCTGCTCGTCC ACATCCCAATGGCCCTGTCCTTTTCTTTACTCArCGCCCTGCTGCTGC CCAAGGTTCACTCTTACCCCTCATCAACCACCCCACCAGCATCTTCGCCATTCCCAATCCCATTCCCCTTTGCTTTAATCATGCCCCTCCTCCTGC 60 30 IGQ 120 laO tcagctccaactcaacctgctctgtcggctgtgatctgcctcaaacccacaccctcgctaccaggaggaccttgatgctcctggcacagatgacgaaaat TCAGCTAGAAGTCATTCACCTCTCrCGCCTGTCATCTCCCTCACACTCACACCCTGCGTAACACGAGCCCCTTCATACTCCTGGCACAAATGCCAACAAr TCACCTACAAATCCATCTGTTCíCTCGGCTGTCATCTCCCTCACaCCCACACCCTCCCTAaTACGAÜCGCCTTGATACTCCTCCCACAAATGGGAAÜAAT TCAGCTGCAAGTCAACCTCCTCTCTCGGCTGTGATCTCCCTCAGACCCACAGCCTCCATAACAGÄGGACCTTCATCCTCCTGGCACAÄATGAGCAGAAt CTGCCTCTGCGCTGTGATCTCCCTCACGCCCACAGCGTGGGTAACACGAGGGCCTTCArACrCCTGACACAAATGACGAGAAT TCAGCTACAAATCCArCTGfTCTCTGGCCTCTGArCTCCCTCACACCCACACCCTGCCTAATACGAGCCCCTTGArACTCCTGGCACAAATGGGAAGAAT TCAGCTGCAAGTCAAGCTGCTCTCTGGGCTGTAATCTGTC7CAAACCCACAGCCTGAATAACAGCAGGACTTTCATGCTCArCGCACAAATCAGGAGAAT 160 130 200 220 240 CTCTCTTTTCTCCTGCTTCAAGCACAGACATGACTTTCGA TTTCCC CAGGAGCAGTTT CGCAACCACTTCCAAAACGCTGAAACCATCCCTGTCCT CTCTCCTTTCTCCTGCCTCaaGGACACaCA rCACTTTCAATTCCCC CACGaGCaCTTTCaTCATAAACaCTTCCACAACCCTCAACCCATCTCTGTCCT CTCTCCTTTCTCCTGCCTGAAGGACACACATGAfTTCCGAATCCCC CACGaCGAGTTTCATCGCAACCAGTTCCACAACCCTCAAGCCATCTCTCTCCT ctctccttcctcctgtctcatggacagacaigactttccatttccc cacgaggagtttcatggcaaccagttccagaaggctccagccatctctctcct CTCTCCTTTTTCTTACCTCAAGGACACACATGACTTTCATTTTCCATCATGAGGTGTTTCATCCCAACCACTTCCAGAACGTTCAAGCTATCTTCCTrrT ctctcctttctcctgcctgaaggacagacatcactttgcattcccc caagacgactttgatcccaaccagttccagaacgctcaacccatctctgtcct CATGACTTTGGATT7CC7 CAGGACGAGTTTCATGGCAACCAGTTCCAGAAGGC7CAACCCATCTCTGTCC7 ctctcctttctcctgcctgaaggacacacatgactttgaatttccc cagoaccaatttgatgccaaccagttccagaaacctcaagccatctctgtcct 260 t 280 t 300 ( 320 340 ccatcacatcatccaccacatcttcaatctcttcaccacaaacgactcatctcctccttgccatcagaccctcctagacaaattctacactgaactctac CCATGAGaTGaTCCaGCACaCCTTCAACCTCTTCAGCACAAAGGACTCA rCTCCTGCTTTGCATCAGACCCTTCTAGATGAATTCTACATCCAACTTGAG CCATCACATGATCCAGCACACCTTCAATCTCTTCAGCACACAGGACTCATGTCCTGC nCGCAACACAGCCTCCTACAAAAATTTTCCACTGAACTTTAC CCATGAGCTGATCCAGCAGATCTTCAACCTCTTTACCACAAAACArTCATGTGCTGCTTGCGATGACGACCTCCTAGACAAAtTCTGCACCGAACTCTAC CCATGAGATGATGCAGCAGACCTTCAACCTCTTCACCACAAAGGACTCATCTGATACTTGGGA'fGAGACCCTTTTAGACAAATCCTACACTGAACrrtAC CCATGAGATGATCCAGCAGACCfTCAATCTCTTCAGCACAAAGGACTCATCTGCTACTTGGCAACACAGCCTCCTAGAAAAATTTTCCACTGAACTTAAC CCATGAűATGATCCAGCAGACCTTCAATCTCTTCAGCACAAAGGACTCATCTCCTACTTGGGATGAGACACTTCrAGACAAATTCTACACTGAACTTTAC CCATGACA FGATGCACCaGaCCTTCAATCTCTTCAGCaC AAAGAACTCArCTGCTGCTTGGGArGAGACCCTCCTAGAAAAATTCTACATTCAACTTTTC 360 380 400 420 440 cagcagctcaatgacctgcaaccctctctcatacacccgctcgcggtgacacacactcccctcatcaaggacgactccaitctcgctctcagcaaatact CAGCAGCTGAATGaCCTGGAAGTCCTGTGTGATCaGGAAGTGGGGGTGATÁGAGTCTCCCCTGATGTACGaCGACTCC ArCCTGGCTCTGAGGAAATACT cagcaactcaatgacctcgaaccatctgtgatacacgaggttggggtcgaacacactcccctgatg aatgaggactccatcctggctgtgagcaaatact cagcacctcaatgacttggaagcctgtgtg atgcaggaggacagggtgggagaaactcccctg atgaatgtggactccatcttggctgtgaagaaatact CAGCACCTCAATGACC7CGAAGCCTC7GTGATGTAGAAGGrTGCAGTGGAAGACACTCCCCTGAGGAA7GTGGACTCCATCCTGGCTGTGACAAAATACT CAGCAGCTCAATGACATCGAAGCCTCCGTGArACAGGAGGTTGGGGTGGAAGAGACTCCCCTGATGAATGTGGACTCCATCTTGGCTGTGAAGAAATACT CACCACCTCAATGACCTGCAAGCCTGTATGATGCACGAGG7TGGAC7GGAaCACACTCCTCTGA7GAATGTGGACTGTATCC7GACTC7CACAAAA7ACT CAGCAAaTCAATCACCTCGAAGCCTGTGTGATACAGGAGGTTGGGGTGGAaGAGaCTCCCCTCATCAATGAGGACTCCATCCTGCCTGTGAAGAAATACT 460 _ 430 ^ 500 ' 520 ^ 540 TCCAAACAATCACTCTCTATC7GAAAGAGAACAAATACACCCCTTG7GCC7GGGACGT7GTCACACCAGAAATCATGAGATC7TTTTCT7TGTCAACAAA tccaaagaatcactctatatctcacagagaagaaatacagctgttctgcctcggaggttctcagagcagaaatcatgauatccttctctttatcaatcaa tccaaagaatcactctttatctaatagagaggaaatacagcccttgtccctgggacgttctcagagcagaaatcatcagatccctctggttttcaacaaa TCCCAAGAATCAC7CTCTATC7GACAGAGAAGAAATACAGCCCrrGTGCC7GGGAGCTTG7CAGAGCAGAAATCATGAGATCCCTCTCTTTATCAACAAA TTCAAAGAATCACTCTTTA7CTGACAAAGAAGAAG7ATAGCCCTTCT7CCTGGCACGCTCTCAGAGCACAAATCATGAGATCC77CTCTTTATCAACGAA TCCAAACAATCACTCTTTATCTGáCAGAGAACAAATACACCCCTTGTGCTTCGGAGGTTCTCACAGCACAaATCATGACATCCTTCTCTTTATCAAAAAT TTCAAAGAATCACCCTCTATCTCACAGAŰAAGAAArACAGCCCTTCTGCATCGGAGGTTCTCACAGCACAAATCATGAGATCCTTCTCTTTATCAGCAAA TCCAAAGAA7CACTCT7TATCTGATGGAGAACAAA7ACAGCCCTTGTGCC7GCGAGCTTC7CAGAGCAGAAATCATCACATCCTTCTCTTTTTCAAC.AAA 560 530 600 ( 520 640 CTTGCAAGAAACTTTAACAACTAAGCAATGAAAACTCGTTCAACATGCAAATGATTTTCATTGATTCGTATGCCAGCTCACCTTTTrATCATCTGCCATT C7TGCAAAAAACAT7GAACACTAAGGAATÜACACC7GGTACAACACCGAAATCAr7CTCATAGACTAATACAGCACTCTACAC7TTGACAACTTGTGCrC cttgcaaaaaagattaacgaggaaggatTüäaaactggttcaacatgccaatgatcctgattgactaatacattatctcacactttcatgagttcttcca CTTGCAAGAAAGATTAACCAGGAAGGAAfÄÄTATCTGGTCCAACATGAAAACAATtCTTATTGACTGATACACCAGGTCACGCTTTGATGAATTCTGXCA CTTGCACGAAACATTAAGCACGAACGAATGAAAACTGGT7CAACATGGAAATCAGAAACAL’TTCCAlGATTAA7ACATCA7C7CACACATTCArGAATTC TTTTCAAGAAAGArTAAGCAGGAAGCAATCAAACCGTTTCAACArGGAAATGATCTCTATTGACTAATACACCAGTCCACACTTCTATGACTTCTGCJAT CTTGCAAGAAAGATTAAGGAGCAACGAATCAAAAC7GGTTCAACATCGAAATGATTCTCArTCACTAGTACACCATTTCACACTTCT7GAGTTC7GCCGT C'rTGCAAAAAACATTAACCAGCAAGGAlTÜAAAACTGG7TCATCA7GCAAATCAT7CTCATTGACTAATACArCATCTCACAC77TCA7GTTCTTCCATT 660 630 700 720 740 TCAAAGACTCATGTTTCTGCXATGACCATGACACCATTTAAATCTTTTCAAATGTTTTrAGGAGTATTAATCAACATTG rATTCAŰCTGTTAAGGCACTA TTTCAAAGACCCTTGTTTCTGCCAAAACCAtCC7ArCAATTCAATCAAATGTGTCAAC7C7TT7CAGGAGTGTTAACCAACATCC7CT7CAGCTGTArCG TTTCAAAGACTCACTTCTATAACCACGACGCCTTGAA7CAAAAT7TTCAAA7CTTT7CACCAC7C7AAACAAGTG7CGTCTA7ACCTGTCCACCCACTAG TTTCAAAGACTCTCACCCCTGCTATAACTATGACCATGCTGArAAACTGATTTATCTATTTAAATATTTATTTAACTATTCATAACATTTAAATTATTTT TCCCATTTCTCATTTTTGCTATA7CCATGACATGAGTTGAATCAAAATTTTAAAATCTTTTCAGGAATGTTAACCAGCATCATGTTCAGCTGTACAGGCA ttcaaagactcatttctcctataaccaccgcatgagttgaatcaaaattttcagatcttttcaggagtgtaaccaaacatcatgtttacctgtccaggca T7CAAATATTAATT7CTCCTATA7CCATGAC7TCAGTTCAATCAAAArTTTCAAACGTTTCACACCrGTTAACCAACACT7CTTTACC7CCACAGCGACA TCAAAGAC7CACTTCTATAACCACCACAAGTTCAATCAAAA77TCCAAA7G7TTTCAGGAG7GT7AAGAAGCATCGTGTTTACC7G7GCAGGCAC7AGTC 760 790 300 320 _ 840 GTCCCT7ACACACGACCATGCTGACTCATCCATTATC7ATTTAAATATTTTTAAAATA7tA77TArT7AACTA7TTATAAAACAACTTArTTTTG7TCA7 CCAC7AGTCCCTTACAGATGACCATGCTCArGCAtC7ArTCArCTAT7TATTTAAATCT77A7TTAC7TAACTACTATACGGACTTAAATTAGTTTTGTT TCCTTTACAGATGAGCAtTCTGATG7CTCTGT7CATCTTTTGTTTAAATATTTATTTAATTA7TT7TAAAATTTATGTAAlA7CATGAŰTCGCT77ACAt TGTTCATaTaaCGTCATGTCCACCTTTACaCTGTCGTTAGTCTAATAáAACATGTTCCTTATATTTACTC-poiy(A) CTAGTTCCTTACGGATGA7CA7GCTGATCGATC7G7TTATCTATT7G7GrAAATAATTATTTAAC7AT7TATAATATTTAAAATCTTCTTTTCATGTATC CTAGTCCT7TACAGATGACCATGC7CATAGATC7AATTArCTArC7Al'7GAAATATTTATTTA777ATTAGAT7TAAAT7A7TT77G7CCArG7AATA7T AAATCT7TACAGATCATCATGCCAATCTATGTA7TCTA7C7AT7tAT:TA7CTG7CTGTCT7CTATCTAA7C7ATTTAAATATTTA7TTATTTAtAAGAT CTTTACACArCACCArTCTGATCTGTCCTTTCATC7AT7TATT7AAArAT7TATTTArT7AACTATTTTTATTATTTAAAT7ArTT77TATGTAATATCA 360 330 _ 900 920 _ 940 aTTACCTCATCTGCaCCTTTGCaCAüTGGTTAATCTaaTAAAATATGTTCTTTGTATTTGGT-oo Ly(A) CATATTATATTArGTGAACT7TTACAT7G7CAATTGrGrAACAAAAACATGT7CT7ATATTTATTA77T7GCCATGTTTA77AAATTT7TACTATCAAAA TGTGG7TAATGTAACAATATATGTTCTTCATATTTAGCCAATATATTAATTTCCTT77TCATTAAAT7TTTACTATAC-poIy(A) aTGTaTTTTTaCTTTGTGGTTaaTATAACaaCaCaTGTTCTTTaT A7T7AG7CAAT AT ATTACTTTCCT7TTTTCATTAAAT7TTTACTATGG-poiy(A) ATGTGTACTTTTACATTGTGT7ATATCAAAATATGTTAATCTAATAT7TACTCAATATA7TATTTTC7TTTTATTAAT7TT7ACTA7TAAAACTTCTTAT TXAAATTATTTTAAACTTATGTTTGTTCAGCTAATAriACATCCACCTTAC TTTGTGCC7AATA7AAT AaaaTATCTTCTTTATGTTTTCTC * po l y ( A) TGAGTACCTTTACATTGTCGT7AATC7AACaaaTATGT 7C T7C AT AT7TACG C AA TAT ATTA AT7TCCT7TTTC ATT A AA77T7T ACT AT - po 1 y ( A) 960 980 1000 AATTCTTTATTTATTCTTTAAAaTTGAACTCCAACCCATGAATTGTGCAAAGTGATTAAAGAATCCATGGT-ooly(A) ATTATTTCCTTATTCTTTAATAAACaAATTCCAaGCCC-po iy(A) 3.óbra
