192846. lajstromszámú szabadalom • Eljárás imidazo [1,2-a]pirimidin származékok előállítására

11

192316

i;

44. példa

{6-allil-5-etil-7-metoxi-imidazo[l,2-a]-pirimidin-2-il)-fenil-metanon. 5

45. példa

[5-{n-butil)-6-etil-7-metoxi-iniidazof 1,2~al~ -pirimidin-2-ni-fenil-metanon. 10

46. példa

r5-(n~butil)-7-Tnetoxi-6~(n-propil)-imidazo[ l,2-a]-pirimidin-2-ill-fenil-metanon

47. példa

[7-metoxi-5-metil-6-(n-pentil)-imidazor 1,2- -al-pirimidin-2-il]-fenil-metanon.

48. példa

[6-(izo~butil)-7-nietoxi-5-metil-iiTiidazoíl,2~-a]-pirimidin-2-il]-fenil-metanon.

1, táblázat

(I) általános képletű vegyületek jellemző adatai

Példa R Rí R2 RaXHozam IR cm'1 (KBr) Op. °C

száma (%)

1-Ph-(CH2)<CH30-52

3120,

1640

234

2-Ph-<CIl2)4-C2H50-48

3120,

1640

250-2

3-Ph-CÏI3

H

CH30-43

3155,

1650

165-6

4-Ph-(CH2)3-CH30-35

3100,

1655

210-1

5-Ph

— (CH2)3

G2HsO-47

3105,

1640

227-9

6-Ph

— { CH2) 3—

CI13S-44

3110,

1640

208-9

7-Ph-ch3

ch3

GH30-76

3140,

1650

198-205

8-Ph-(CH2)5-CH30-44

3120,

1630

196-8

9-Ph-CHs-CH2Ph

CH30-55

3110,

1640

199-202

10-Ph-(CH2)5-C2H50-39

3130,

1640

193-4

11-Ph-CII3-CII(CIl3)2

CH30-48

3120,

1640

148-50

12-Ph-(CH2).!CH3S-35

3180,

1639

225

13-Ph-(CH2)3

C2Il5S-63

3100,

1630

211-2

14-Ph-C3H7

I-I

CI130-37

2950,

1640

152-4

15-Ph-C2H5

II

CH30-49

3110,

1640

179-82

16-Ph-CHs-C2Hs

CH30-68

3120,

1640

148-50

17-Ph-CH2CH(CH3)CII2CH2-CH30-43

3110,

1640

200-1

18-Ph-CH2CH(CH3)CH2CH2-CH3S-52

3110,

1630

215-7

19-Ph-CII3

n-hexil

CH30-42

3130,

1630

122-6

20-Ph-CH3

GH2=CHCH2-CH30-68

3120,

1640

128-31

21-Ph-CII3

H

CH3S-58

3100,

1640

170-2

22-Ph-C3H7

H

CH3S-72

3160,

1650

162-3

23-Ph-CHS

ciklopropil metil-CH3O-32

3120,

1640

136-7

24-Ph-ch3

(n) képletű csoport

CÍI3O-55

3130,

1645

169-70

25-Ph-CH3-C2H5

C2H5O-23

3120,

1640

154-9

26-Ph-C3H7-CH3

CH3O-40

3120,

1640

140-1

27-Ph-C3H7

■-C2H5

CHjO-36

3120,

1635

122-3

28-Ph

II

H

CHaO-84

3120,

1640

209-9

29-Ph-C2Hs-CIÍ3

CH3O-31

. 3120,

1641

174

30-Ph-CII3-C4H9

CH3O-26

' 3120,

1640

141-5

31-Ph

C2H5-C2H5

CH3O-23

3155,

1642

141-2

32-Ph

—CH3-C3H7

CH3O-54

3120,

1640

141-2

33-Ph

— C3H7

~C31Í7

CII3O-31

3130,

1640

123-4

34-Ph-C3H7

~C,H9

CH3O-30

3120,

1635

113-4

35-Ph-C2II5-C3IÍ7

CH3O-26

3120,

1635

151-2

36-Ph-C2II5

—C4II9

CH3O-20

3130,

1635

158-9

37-Ph-C3II7-aim

CII3O-40

3140,

1640

122-3

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