191658. lajstromszámú szabadalom • Eljárás cefém-karbonsav-származékok előállítására
1 191 658 2 3,75 (2H, S, C//2SO) 1,45 (3H, D, J = 7 Hz, CZ/3CH). SR 42 222 NMR-spektruma (16) 250 MHz-< 8,61 (1H, D, J = 9 Hz, CON//) 8,40 (5H, S.e., N//3+, C02//) 7,95 (2H, D, J = 8 Hz, H orto CO) 7,61 (2H, D, J = 8 Hz, H meta CO) 7,30 (3H, S.e., N//3+) 6,76 (1 H, S,//tiazol) 5,92 (1 H, DD, J, = 9 Hz, J2 = 4 Hz, //7) 4,93 (1H,D, J = 4Hz,//6) 4,42 (1H, D, J = 13 Hz, C//2SCO) 4,10 (2H,S.e.,C^2NH2) 3,92 (1H, D,J = 13Hz,C//2SCO) 3,74 (2H, S, C//2SO) 2,35 (4H, M, (a)) 1,85 (2H, M, (b)). SR 42 531 NMR-spektruma (17) 250 MHz-en: 5 (ppm) 8,62 (1H, D, J = 9 Hz, CON//) 8.20 (3H, S.e., CII2N//3+) 8.00 (1H, S.e., aromás//2'-helyzetben) 7.90 ( 1 H, D, J = 8 Hz, aromás // 6'-helyzetben) 7.72 (III, D, J = 8 Hz, aromás H 4'-helyzetben) 7.55 (1H, T, J = 8 Hz, aromás//5'-helyzetben) 6.93 (1H, S,//tiazol) 5.95 (1H, DD, J] = 9 Hz, J2 = 4 Hz,//7) 4.93 ( 1 H, D, J = 4 Hz, //6) 4.43 (1H, D, J =13 Hz, C//2SCO) 4.10 (2H,Q,J = 7Hz,C//2NH3+) 3.94 (1H, D, J = 13 Hz, C//2SCO) 3.75 (2H, S.e., C//2SO) 1,45 (6H, 2S, (C//3)2C). SR 42 532 NMR-spektruma (18) 250 MHz-en: 6 (ppm) 8.80 (1H, D, J = 9 Hz, CON//) 8.20 (3H, S.e., CH2N//3+) 8.00 (1H, S.e., aromás//2'-helyzetben) 7.90 ( 1 H, D, J = 8 Hz, aromás H 6'-helyzetben) 7.72 (1 H, D, J = 8 Hz, aromás H 4'-helyzetben) 7.55 (III, T, J = 8 Hz, aromás H 5'-helyzetben) 6.92 (1H, S,// tiazol) 5.94 (1 H, DD, Ji = 9 Hz, J2 = 4 Hz, //7) 4.96 (1H, D, J = 4 Hz,//6) 4.44 (1H,D, J = 13Hz,C//2SCO) 4.10 (2H, Q, J = 7 Hz, C//2NH3+) 3.94 (III, D, J = 13 Hz, C//2SCO) 3,77 (2H, S.e., C//2S0) 2,40 (4H, M, (g)) 1.90 (2H, M, (h)). SR 42 533 NMR-spektruma (19) 250 MHz-en: 5 (ppm) 8.80 (2H, S.e., N//2+CH3) 8.60 (III, D, J =9 Hz, CON//) 7.95 (2H, D, J = 8 Hz, aromás H 2'- és 6'-helyzetben) 7.60 (2H, D, J = 8 Hz, aromás H 31- és 5'-helyzetben) 6.94 (1 H, S,//tiazol) 5.95 (1 H, DD, J, = 9 Hz, J2 = 4 Hz, //7) 4.95 (111, D. J = 4 Hz,//6) 4,42 (1H, D, J = 13 Hz, C//2SCO) 4,16 (2H,T, J = 7 Hz, C//2NH2CH3) 3.92 (1H, D, J = 13 Hz, C//2SCO) 3.75 (2H, S.e., C//2SO) 2.55 (3H, T, J = 7 Hz, CH2NH2+C//3) 1.45 (6H, 2S,(CH3)2C). SR 42 534 NMR-spektruma (20) 250 MHz-en: 6 (ppm) 8,84 (1H, D, J = 9 Hz, CON//) 8 80 (2H, S.e., N//2+CH3) 7,95 (2H, D, J = 8 Hz, aromás H 2'- és 6'-helyzetben) 7.60 (2H, D, J = 8 Hz, aromás H 3 - és 5'-helyzetben) 6.95 (1H, S,//tiazol) 5,94 (1H, DD, J] = 9 Hz, J2 = 4 Hz, Z/7) 4.95 (1H, D, J = 4 Hz, U6) 4,45 (1H,D,J = 13fe, C//2SCO) 4,16 (2H, T, J = 7 Hz, C//2NH2+CH3) 3,92 (1H, D, J = 13 Hz, C//2SCO) 3,75 (2H, S.e., CH2 SO) 2,55 (3H, T, J = 7 Hz, CH2NH2+C//3) 2 40 (4H, M, (g)) 1 90 (2H, M, (h)). SR 42 535 NMR-spektruma (21) 250 MHz-en: 5 (ppm) 8 66 (1H, D, J = 9 Hz, CON//) 8 10 (3H, S.e., CHsN/V) 7.55 (2H, M, aromás H 2'- és 6'-helyzetben) 7.37 (1H, T, J = 8 Hz, aromás H 5'-helyzetben) 6.95 (1H,S,//tiazol) 5.96 (1 H, DD, Jj = 9 Hz, J2 = 4 Hz, //7) 4.96 (1H, D, J = 4 Hz, Z/6) 4.39 (1H, D, J = 13 Hz, C//2SC0) 4.07 (2H, M, aromás C//2NH3+) 3,90 (1H, D, J = 13 Hz, C//2SCO) 3.78 (2H, S, C//2SO) 2,26 (3H, S, aromás C//3) 1.45 (6H, 2S, (C//3)2C). SR 42 536 NMR-spektruma (22) 250 MHz-en: 6 (ppm) 8.89 (1H, D, J = 9 Hz, CON//) 8,10 (3H, S.e., CHîNZ/j") 7.55 (2H, M, aromás H 4'- és 6'-helyzetben) 7.37 (1H, T, J = 8 Hz, aromás H 5'-helyzetben) 6.95 (1H, S,//tiazol) 5.95 (1H, DD, Jj = 9 Hz, J2 = 4 Hz,//7) 5,00 (1H, D, J = 4 Hz,H_6) 4.40 (1H, D, J = 13 Hz, C//2SCO) 4,05 (2H, M, aromás C//2NH3+) 3.90 (1H, D,*J = 13 Hz, C//2SCO) 3.79 (2H, S, CH2SO) 2.40 (4H,M,(g)) 2,25 (3H, S, aromás C//3) 1.90 (211, M, (h)). SR 42 659 NMR-spektruma (23) 250 MHz-en: 5 (ppm) 8,64 (1H, D, J = 9 Hz, CON//) 8,14 (3H,S.e.,CH2N//3+) 7.95 (1H,S, aromás//2’-helyzetben) 7,60 (1H, D, J = 8 Hz, aromás H 6’-helyzetben) 7,39 (1H, D, J = 8 Hz, aromás H5'-helyzetben) . 6,95 (1H, S,//tiazol) 5.95 (1H,DD,Ji = 91Iz,J2 = 4Hz,//7) 4.96 (III, D, J = 4 Hz,//6) 4.37 (1H,D, J = 13Hz,C//2SCO) 4.08 (2H,M,C//2NH3+) 3,94 (1H, D, J = 13 Hz, C//2SCO) 3,74 (2H, S.e., C//2SO) 2.37 (3H, S, aromás C//3) 1.45 (6H, 2S, (C//3)2C). SR 42 660 NMR-spektruma (24) 250 MHz-en: 6 (ppm) 8.80 (1H, 2D, J = 9 Hz, CON//) 5 10 15 20 25 30 35 40 45 50 55 60 65 43
