191658. lajstromszámú szabadalom • Eljárás cefém-karbonsav-származékok előállítására

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191 658

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SR 42 396 NMR-spektruma (73) 250 MHz-en: S (ppm) 8,70 (1 H, D, J = 9 Hz, CON//)

7,95 (2H, D, J = 8 Hz, aromas H 2'- és 6'-helyzetben) 7,67 (2H, D, J = 8 Hz, aromas H 3'- és 5’-helyzetben) 6,92 (1H,S, //tiazol)

6.00 (1 H, DD, Ji = 9 Hz, J2 = 4 Hz, //7)

5,43 (111, D,J = 13Hz,C//2OCO)

5.00 (1H, D, J = 4 Hz, //6)

4,82 (1H, D, J = 13 Hz, C//2OCO)

4,18 (2H,M, aromás C//2)

4,10 (lH,D,J = 17Hz,C//2SO)

3,76 (1H, D, J = 17 Hz, C//2SO)

2,90 (2H, M, CH3C//2NH)

1,47 (6H, 2S, (C//3)2C)

1,16 (3H, T, J = 7 Hz, C//3CH2).

SR 42 397 NMR-spektruma (74) 250 MHz-en: 8 (ppm)

8,70

(1H, D,J =

9 Hz, CON//)

7,95

(2H,D,J =

8 Hz, aromást2'-és 6'-helyzetben)

7,67

(2H, D, J =

8 Hz, aromás H 3'-és 5'-helyzetben)

6,95

(1H, S, H tiazol)

6,00

(1H, DD, Jj

, = 9 Hz, J2 = 4 Hz,

Hn)

5,45

(1H, D, J =

13 Hz, C//2OCO)

5,00

(1H, D, J =

4 Hz, H6)

4,82

(1H, D, J =

13 Hz, C//2OCO)

4,16

(2H, M, aromás CH2N Pr)

4,08

(1H, D, J =

17 Hz, C//2SO)

3,78

(1 H, D, J =

17 Hz, C//2SO)

3,20

(1H,M, NH

[-C//-(CH3)2)

1,48

(6H, 2S, (C//3)2C)

1,26

(6H,D,J =

7 Hz, (C//3)2CH).

SR 42 456 NMR-spektruma (75) 250 MHz-en: Ô (ppm)

8,62

(1H, D, J

= 9 Hz, CON//)

8,10

(3H, S.e.,

CH2N H3+)

7,68

(1H,D,J

— 7 Hz, aromás H 6'-helyzetben)

7,55

(1 H, D, J

= 7 Hz, aromás H 4'-helyzetben)

7,34

(1H, T, J

= 7 Hz, aromás H 5'-helyzetben)

6,92

(1H,S,//tiazol)

6,00

(1H, DD,

J1 = 9Hz,.T2 = 4Hz,//7)

5,37

(lll.D.J

= 13 Hz, C//2OCO)

5,00

(111, D,J

= 4 Hz,H6)

4,84

(1H, D, J

= 13 Hz, C//2OCO)

4,10

(3H, M, C//2NH3 és C//2SO)

3,75

(1H, D,J

= 17 Hz, C//2SO)

2,40

(3H,S, aromás C//3)

1,47

(6H, 2S, (C//3)2C).

SR 42 457 NMR-spektruma (76) 250 MHz-en: 5 (ppm)

8,62

(1H, D,J

= 9 Hz, CON//)

8,00

(3H, S.e.,

CH21W3+)

7,31

(1H, D, J

= 7 Hz, aromás H 4'-helyzetben)

7,14

(1H, D, J

= 7 Hz, aromás H 5 '-helyzetben)

6,90

(1H,S, //tiazol)

6,00

(1H, DD,

Ji = 9 Hz, J2 = 4 Hz, //7)

5,27

(1H, D, J

= 13 Hz, CH2OCO)

5,00

(1H,D,J

= 4 Hz,//6)

4,92

(1H,D,J

= 13 Hz, C//2OCO)

4,00

(311, M, C//2NH3+ és C//2SO)

3,64

(1H, D, J

= 17 Hz, C//2SO)

2,18

(6H, S, aromás C//3)

1,48

(6H, 2S, (C//3)2C).

SR 42 458 NMR-spektruma (77) 250 MHz-en: 8 (ppm)

8,65 (1H,D, J = 9 Hz, CON//)

28

7.90 (3H,S.e.,CH2N//3+)

7.00 (1H,S, aromás//)

6.90 (ÍH.'S, /Ztiazo!)

6.00 (1H, DD, Ji = 9 Hz, J2 = 4 H:,//7)

5.25 (lH,D,J = 13Hz,C//2OC.';>)

5.00 (1H,D,J = 4Hz,/76)

4.92 (1H,D,J = 13Hz,C//20;0)

4.00 (3H,M, aromás C//2NH3' és C//2SO)

3,65 (1H, D, J = 17 Hz, C//2SO)

2,31 (3H,S, aromás C//3)

2.25 (3H, S, aromás C//3)

2,14 (3H, S, aromás C//3)

1.45 (6H, 2S, (C//3)2C).

SR 42 459 NMR-spektruma (78) 250 MHz-en: 8 (ppm)

8,70 (lH,D,J = 9Hz,CON/7)

8.00 (3H, S.e., CH2N//3+

7.45 (1H, D, J = 7 Hz, aromás H 4'-heiyzetben)

6.92 (2H, M,//tiazol és aromás H 5'-helyzetben)

6.00 (1H, DD, Jj = 9 Hz, J2 = 4 Hz,//7)

5,42 (1H, D, J = 13 Hz, C//2OCO)

5.00 (1H, D, J = 4 Hz,//6)

4.84 (1 H, D, J = 13 Hz, C//2OCO)

3.95 (3H, M, C//2NH3+ és C//2SO)

3,78 (3H,S, OC//3)

3,73 (3H,S, OC//3)

3,58 (1H, D, J = 17 Hz, C//2SO)

1.47 (6H, 2S, (C//3)2C).

SR 42 460 NMR-spektruma (79) 250 MHz-en: ô (ppm)

8,62 (1H, D, J = 9 Hz, CON//)

8.00 (5H, M, CH2N//3+ és aromás H 2'-és 5'-helyzetben)

7,20 (1H, D, J = 7 Hz, aromás H 5'-helyzetben)

6.95 (1H, S, //tiazol)

6.00 (1H, DD, Jj = 9 Hz, J2 = 4 Hz,//7)

5.45 (1H, D, J = 13 Hz,C//2OCO)

5.00 (1H,D,J = 4Hz,//6)

4.82 (1H, D, J = 13 Hz, C//2OCO)

4.00 (3H, M, C//2NH3+ és C//2SO)

3,88 (311, S, 0C//3)

3,72 (1H, D, J = 17 Hz, C//2S0)

1.48 (3H,S, (C//3)2C)

1.47 (3H, S, (C//3)2C),

SR 42 461 NMR-spektruma (80) 250 MHz-en: 5 (ppm)

8,66 (1H, D, J = 9 Hz, CON//)

8,05 (3H, S.e., CH2N//3+)

7,50 (3H, M, aromás H)

6.95 (1H, S, H tiazol)

6.00 (1H, DD, Jj = 9 Hz, J2 = 4 Hz, //7)

5.45 (1H,D,J = 13Hz,C//2OCO)

5.00 (1H, D, J = 4 Hz,//6)

4.84 (1H, D, J = 13 Hz, C//2OCO)

4.00 (3H,M, C//2NH3+ és C//2SO)

3,86 (3H, S, C//30-aromás)

3,75 (1H, D, J = 17 Hz, C//2SO)

1.48 (3H, S, (C//3)2C)

1,47 (3H, S, (C//3)2C).

SR 42 462 NMR-spektruma (81) 250 MHz-en: S (ppm)

8.82 (1H, D, J = 9 Hz, CON//)

8,20 (3H, S.e., CH2N//3+)

8,13 (1H, S.e., aromás H 2'-helyzetben)

7.95 (1H, D, J = 7 Hz, aromás H 6'-helyzetben)

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