191378. lajstromszámú szabadalom • Eljárás vinil-tio-acetamido-oxa-cef-3-ém-4-karbonsav-származékok előállítására

III. táblázat foly tatása

Vegyület

száma

w

ÍR

NMR

3—33

3-34

5-3:

3-36

3-37

253- H H dioxo- 4-etilpiperazin- 1 'il-karboniia mino-Cl-NH H H

I

co

I

oc2h5

n3 h h-SC1

Cl-CHO

Cl-CH

1

Ph,-STctCHi

CH -STetCHa

I

Ph2-CH

1

Phi

STetCH,-CH

I

Pha-STetCHj

Nujol:

3150,1780, 1705,1670

Nujol:

3380,2110, 1790,1710

CDCI3 :

1,13 (bt, 3H, J = 6), 3,57 (s, 3H), 3,80 (s, 3H), 3,2-4,3 (m, 6H), 4,23 (bs, 2H), 4,62 (bs, 2H),

5, 12 (s, 1H), 5,93 (d, 1H, J = 7), 6,02+6,27 (d, 1H,

J = 6), 6,63 (d, 1H,

J =6) 6,90 (s, 1H), 7,2—8,0 (m, 11H)

CDCI3 :

1,20+1,25 (t, 3H,

J = 7.5), 3,55+3,56 (s, 3H), 3,78 (s, 3H), 4,0-4,4 (m, 2H) 4,27 (s, 2H), 4,62 (s, 2H), 5,10 (s,

1H) 5,80 (d, 1H,

J = 8), 6,10+6,28 (d, 1H, J = 6), 6,60 (d, 1H, J = 6),

6,90 (s, 1H), 7,3- 7,8 (m, ! 1H)

3,57 (s, 3H), 3,75 (s, 4H), 4,23 (s, 2H), 4,65 (s, 2H), 5,10 (s, 1H), 6,13+ 6.12 (d, 1H, J = 7), 6,62 (d, 1H, J = 7), 6,90 (s 1H), 7,2— 7,7 (m, 11H)-CH2

1

Cl-CH

\-STetCHj

CHCI3 :

CDCI3 :

1

OH

!

Ph2

3600,3375,

3.60 (s, 3H), 3,78

1795.1728. (s, 3H), 4,18 (s.

1702,1640, 2H). 4,25 (s, 2H).

4,65 (s, 2W),4,80 (s, 1H), 5,10 (s, 1H). 6,87 (s, 1H), 7,2-7,6 (m 10H), 7,93 (s, Hl)

CHC!j:

1785,1720, 1700

CDCI3:

3,58 (s, 3H), 3,80 (s, 3H), 4,23 (s, 2H), 4,63 (s, 2H), 5,08 (s, 2H), 6,9 (s, 1H), 7,7—7,1 (m, 10H), 9,25 (s, 1H)

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