191378. lajstromszámú szabadalom • Eljárás vinil-tio-acetamido-oxa-cef-3-ém-4-karbonsav-származékok előállítására

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II. táblázat folytatása

Vegyület u v w x y 7. IR NMR

szama

2-75 H H H F

2-76 H H -CO F

I

nhch3

2-77 H H -CO F

I

nhch3

2-78 H H H F

2-79 H H NHjCO— F

2-80 H H NMjCO- F

Na -STctCHjNHCO I

HOCHiCHjNH

KBr:

3380,1767. 1675,1630 (sh) 1610

Na ~ STetCHjCONHj KBr:

3400,1770, 1688,1614

Na -STetCHjCONH

I

cn3

Nnjol :

3250,1765, 1670,1610

Na (4-hidroxi- KBr:

5-piridil)- 3400,3250, amino-kar- 1768,1687, bonil- 1632,1610 melil- tetrasolil-Fo-H -STetCHiCIljOH

11 -STetCHjCUjOCO

I

OCIljPh

Nujol:

3300,1777, 1740,1680, 1620

D20:

3,97 (s, 5H), 3,70-4,27 (m 411), 4,65 (bs, 2H), 4,95 (bs, 211), 5,60 (s, 1H), 5,70 (s, 2H), 6,03 (dd, 1H, J = 4,40), 7,30 (dd, 1H, J = 4,82)

D20:

3,23 (s,3H), 4,12 (s, 2H), 4,50-4,70 (m. 211). 4,90 (bs, 211), 5,57 (s, HÍ), 5,70 (s. 211), 7,21 (d, 1H,

J = 34)

DjO:

3,23 (s, 6H), 3,95 (s, 3H), 4,13 (s, 2H), 4,53-4,72 (m, 2H), 4,90 (bs, 2H), 5,55, (s, 1H), 5,63 (s, 2H), 7,20 (d, III, J = 34)

CD3COCD3 :

3,53 (s,3H),

3,75 (s,2H),

3.88 -4,77 (m, 8H), 5,10 (s, 111), 6,90-7,20 (m, 211), 7.05 (d, 1H,

J =34), 8,10-8,47 (m, 1H)

CO.3CÜCÜ3:

3,50 (s, II), 3,70 (s, 2H), 4,33 (s,

2H), 4,6á (bs, 6H), 5,10 (s, 1H). 5,13 (s, 211), 7,03 (d, 1H), J =34). 6,87-7,17 (m, 2H), 7,37 (s,5H), 8,20-8,43 (m, 1H)

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