191378. lajstromszámú szabadalom • Eljárás vinil-tio-acetamido-oxa-cef-3-ém-4-karbonsav-származékok előállítására

191 3/fc

IL táblázat folytatása

Vegyidet uv w x y z ÍR NMR

szama

2-55 H H -NH2CO F Na -STetCH2CH2 OH

KBr: D20:

3400, 1770, 3,97 (s, 3H), 4,17 (s, 2H),

1680,1605 4,33-5,10 (m,8H), 5,58

(s, lH),7,30(d, 1H,J = 34)

2-56 H H -NH2CO F Na

2-57 H H -CONHCHj F H

2-58 H H -CONH2 F H

2-59 H H H F H

2-60 H H H F Na

2-61 H H H F H

3: ctCH2CONHj

KE;:

D2 O:

3375,1765,

3,97 (s, 3H), 4,15 (s, 2H),

1685,1607

4,50,4,77 (ABq, 2H, J = 13), 4,92 (bs,2H), 5,57 (s, 1H), 5,70 (s,2H),7,27 (d, 3 H, J =34)

STctCHjCHCHj

Acetcn-d6;

2,76 (d, 3H, j = 4), 3,46 (s, 3H), 3,68((s, 2H), 4,37 (s, 2H), 4,67 (s, 2H), 4,9-6,5 (m. 6H), 6,92 (d, IH, J = 35), 7,5 (brs, 1H), 8,2 (brs, 1H)

STetCH2CH=CH2

Aceton-d6:

3,49 (s, 311), 3,70 (s, 2H), 4,37 (s, 2H). 4,66 (s, 2H).

4,9-6,2 (m,6H),7,0 (d, IH. J = 36), 8,29 (s, IH)

■STetC!I,CH=CHj

Aceîon-d6:

3,50 (s, 5H), 4,36 (s, 2H),

4,17 (s, 2H). 4,9-6,2 (m, 5H), 5,76 (dd, IH, 1J = 42,6),

6,84 (dd, IH, J = 83,6),

8,16 (s, 1 H)

■SïetCH2CONH

D20:

H !

HjNCOCHî

4,00 (s, 5H), 4,46 (.s, 2H1,4,67 (d, 2H, J = 6), 4,96 (s, 2H), 5,63 (s, III), 5,84 (s,2H),

6,07 (dd, IH, J --39,5), 7,35, (dd, IH, J = 83,5)

STeíCH2CONH

1

Aceton-dô:

1

HjNCOCHî

3,50 (s, 3H), 3,78 (s, 2H),

3,99 (d, 2H, J = 6), 4,30 (s, 2H), 4,63 (s, 2H), 5,13 (s, III), 5,30 (s,2H), 5,77 (dd, IH, J = 40,4) 6,4-8,3 (m,

4H)

20