191378. lajstromszámú szabadalom • Eljárás vinil-tio-acetamido-oxa-cef-3-ém-4-karbonsav-származékok előállítására

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II. táblázat

(I) általános képlet

Vegyület u v w x y z IR NMR

száma

2-1 H H H -CF3 Na

2-2 H H H Cl H

2-3 H H H Cl H

2-4 H H H Cl H

2-5 H H H Cl H

2-6 H H H Cl H

2-7 H H H Cl H-STctCHj

Nujol (y=H): 3200,1775, 1700,1670, 1610

DjO:

3,93 (s,3H), 4,05 (s, 2H),

4,43 (s, 3H), 4,57 (s, 2H),

4,95 (bs, 2H), 5,58 (s, 1H), 5,77- 6,60 (m, 1H), 7,25-7,60 (m, 1H)-OCONHj

Aceton-d6:

6,67 (d, 1 H, J = 7), 6,18 (d, 1H, J =7), 5,03 (s, 1H), 4,98 (s,2H), 4,48 (s, 2H), 3,56 (s,3H)

—S — 2—indolil

Aceton-d6:

8,03 (s, 1H), 7,7-6,6 (m, 5H), 6,15 (d, 1H, J = 7), 5,02 (s, 1H), 6,13 (s,2H), 4,13+3,83 (ABq, 2H,J = 13), 3,75 (s, 2H), 3,56 ( s, 2H), 3,45 (s, 3)

(a)

Nujol:

3300,1680, 1630

Aceton-d6:

3,47 (s, 3H), 3,57 (s, 2H), 4,18 (d, 1H, J = 14), 4,67 (s, 2H), 5,10 (s, 1H), 4,83-5,63 (m,'2H), 6,18 (d, 1H,J = 6), 7,03-7,43 (m,2H)

4-me til-lH- 1,2,4-triazol-2-11 tio-Aceton-d6:

3,48 (s,3H), 3,58 (s, 2H),

3,78 (s, 311), 4,10 (d, 1H,J = 13), 4,35 (d, III, J = 13),4,63 (s,2H), 5,07 (s, 1H), 6,23 (d, 1H,J=6,5) 6,73 (d, 1H, J = 6,5), 6,92 (bs, 2H), 8,68 (s, 1H)

(b)

Aceton-d6:

3,48 (s, 3), 3,56 (s, 2H), 3,70 (s, 3H). 4,18 (d, 1H. J = 13), 4,45 id, 1 H, J = 13), 4,63 (s, 2H), 5.10 (s,, 1111,4,93-5,67 (m,22H), 6.23 (d. 1H,J=7), 6,73 (d, 1 H, J = 7), 7,93—8,33 (m, IH)-STetCH.-,

Nujol:

3220,1775, 1705

Aceton-d6:

3,48 (s, 311), 3,58 (s, 2H), 4,00 (s, 311), 4,33 (s, 211), 4,67 (s, 211), 5,10 (s, 1H), 6,23 Cd, 111, J --6), 6,75 (d, 1H, J = 6), 7,22 (bs, ÍH)

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