190898. lajstromszámú szabadalom • Antidotumként 8-oxi-kinolin-származékokat tartalmazó készítmények, valamint eljárás a 8-oxi-kinolin-származékok előállítására

zárt

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190.898

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R6 X

H-CH(CH3)H-CH(CH3>H-ch2-H-CH(CH3)H-CH(CH3)H-CH(CH3)H-CH(CH3)~

H-CH(CH3)H-CHH-CH(CH3)H-CH(CH,)H-CH(CHj)H-CH(CH,}H-CH(CH')H-CHH-CH(CH,1-H-CH(CH3)H-CH(CH,)H-CH(CH,)H-CH(CH3)H-CH(CH3)H-CH(CH3)H-CH(CH3)H-CH(CH3)H-CH(CH3)H-ch2-H-CH(CH3)H-CH(CH3y-H-CH(CHj)H-CH(CH3)H-CH(CH,)H-CH(CH3)H-CH(CH3)H-CH(CH3)~

H-CH(CH3)H-CH(CH3)H-CH(CHj)H-CH(CH3)H-ch2-H-CH(CH3)H-CH(CH3)H-CH(CH3)H-ch2-H-CH(CHj)H-CH(CH3)H-CH(CH3)H-CH(CH3>H-CH(CHj)H-CH(CH,)H-CH(CH3)H-CH(CH,)~

H-CH(CH'3)H-CH(CH3)H-CH(CH,)H-CH(CH3)H-CH(CH3)H-ch2-H-CH(CH3)H-ch2-H-CH(CH3)H-CH(CH3)H-CH(CH3)H-ch2-H-CH(CH3)H-ch2-H-CH(CH3)Y-COOCH,-C(CH3) = ch2

00-CON(C2H5)2

(1)-COOCH2CH2OCH3

(m)-COOCH2CH2OCH3 -CON H-C(C2H5)2-CH2OH-conh2

(n)

(o)-CONHCH2CH2OCH3-CONH(CH,)3OH

(p)-COOCH2CH2OC2H5-conh2

(q)

(0-cooch3

(0-CONH(CH2)3OCH3

(t)-cooc2h,-CONHCHj

O)-CONH(CH2)3CH3

(V)

(z)

00-COOC3H7n-CONH(CH,)3--N(CH2CH2ÖH)j-COOC3H7ízo

(y)-CON(CH2CH2OCH3)2-CONH(CH2)3NHCH3-COOCH2CH2Br-CONHCHj-COO(CH2)4OH

(z)

(aa)

(bb)-COOCH2-CsC-CH2OH

(b)-COOÇ,H,n

(cc)

(bb)-CON(CH3)2 -CONH(CH7)3CH3 • H,0 (dd)

(ee)-conh2

(ff)-COOCH,CH2OC2H5-COS(CH2)3CH3

(gg)

(hh)-cooch3-COOCH2CH2OC4H,n-COOC2H5-cooch2ch2ci

(ii)

(jj)-COOC3H7n

(kk)-CONHCH,

(II)

Fizikai

állandó

op.: 120-122 °C n54 = 1,5673

op.: 88-90°C

op.: 66-68°C ni2 = 1,6054

op.: 146-149 °C

op.: 73-76°C

9