189531. lajstromszámú szabadalom • Eljárás alanin-származékok előállítására

189 531

Szám n

R1

R2

j^3 Módszer

MMR spektrum

214 1 —CH,

215 1 H2N—(CH,)*—

H -C2H5

CH2—CH2—CON— -(4-fluor-fenil)

H

I

CH,—CH,—CON—

A 7,3-6,9m (8H); 2,lm (2H); l,5m (2H); l,2d (3H)

—C2H5 B 7,3-6,8m (8H); 2,4-2,lm (4H); 1,7-1,3m (8H)

—(4-fluor-fenil)

216

1 -ch3

—ch2—ch2—conh—

—QH5

A

7,2-6,4m (8H); 3,9s (3H);

—(4-metil-fenil)

2,lm (2H); 1,5m (2H); l,2d (3H)

217

1 —ch3

—ch2—ch2—CONH—

—H

A

7,3-6,3m (8H); 2,lm (2H);

—(2-hidroxi-fenil)

l,5m (2H); l,2d (3H)

218

1 —ch3

H

1

—H

A

7,3-6,4m (7H); 3,9s (3H):

2,lm (2H); 1,5m (2H); 1.2d

—CH2—CH2—CON — —(2-metoxi-5-klór-feníl)

(2H)

219

X

u

1

0 H

—H

A

7,7-7,0m (8H); 2,1m (2H); l,5m (2H); l,2d (3H)

—CH2—CH2—C — N — —(4-karbamoil-fenil)

220

1 -ch3

H

— H

A

7,6-7,Om (8H); 4,2q (2H);

1

2,lm (2H); 1,5m (2H);

—CH2—CH2—CO—N— —(4-etoxi-karbonil-fenil)

l,2d +1 (6H)

221

1 -CH3

O H

—H

A

7,3-6,4m (8H); 3,9-3.0in + q

Il 1

(6H); 2,lm (2H); 1.5m (2H)

—CH2—CH2—C—N— —(4-etoxi-fenil)

1,2d +1 (6H )

222

1 -CH3

H

— H

A

8,2-6,9m (8H); 2,lm (2H); l,5m (2H); l,2d (3H)

—CH,—CH2—CON— —(3-nitro-fenil)

223

1 -CH3

H-C2H5

A

7,3-6,3m (7H); 3,8s (6H);

2,lm (2H); 1,5m (2H); l,2d

—CH2—CH,—CON— —(3,4-dimetoxi-fenil)

(3H)

224

1 — ch3

H

1

—c,h5

A

7,3-6,2m (6H); 3,9s (9H):

2, lm (2H); 1,5m (2H); 1.2d

—CH2—CH,—

CON — —(3,4,5-trimetoxi-fenil)

(3H)

225

1 -ch3

H

1

—CH2—CH,—CON —

—H

A

2,8-2,2m (3H); 1,5m (2H); l,2d (3H); l,0d (6H)

CH(CH3)2

226

I -CH3

H

—H

A

7,4-7,0m (9H); 5,l-4,3m + s

1

—CH2—CH,—CON— —CH2-fenil

(5H); 2,lm (2H); 1,5m (2H) l,2d (3H)

27