189531. lajstromszámú szabadalom • Eljárás alanin-származékok előállítására

189 531

Szám n R1 R2 R3 Mód

szer

92

0

—ch3

H H-c2h5

A

.—

1 J

ch2—ch2—n—co—n—

:—

(3-nitro-fenil)

93

0-ch3

H H-c2h5

A

r-1 1

ch2—ch2—n—co—n—ch3

94

0-ch3

—CH2—CH2—(1-hexahidropiridil)-c2h5

A

95

0-ch3-c2h5

A

—CH2—CH,—N-fenil

96

0

—ch3

H-c2hs

A

—ch

2—ch2—n

—(2-klór-fenil)

97

0

—ch3

H-c2h5

A

—CH2—CH2—N— —(4-metoxi-fenil)

98

0

—ch3

(CH2)5 nh2

—H

c

99

0

—ch3

(ch2)4 nh2

—H

c

100

1-ch3

—CH2—S-fenil-c2h5

A

101

1-ch3

—CH2—S—(4-fluor-fenil )-c2h5

A

102

1-ch3

—CH2—SH-c2h5

A

103

1-ch3

—CH2—S—(4-szulfamoil - fenil)-c2h5

A

104

1

(CH3)2CH- —CH2—S—(3-metoxi-c2h5

A

—ch

2

fenil) .

105

1

(1) képletü

cső- —CH2—S—(3-karbamoil-c2h5

A

port

fenil)

106

1

(3) képletü port

cső- —CH2—S—(3-nitro-fenili-c2h5

A

107

1

(3) képletü

cső- —CH2—S—(3-amino-c2h5

A

port

fenil)

108

1

(CH3)2-—CH2—S—(2-metil-fenilj-c2h5

A

—CH—CH2

109

1-ch3

—CH2—S—CH2-fenil-c2hs

A

110

1

benzil—CH2—S—CH(CH3)2-c2h5

A

111

1

—ch3

—ch2—s—ch2—ch2—-N(CH3)2-c2h5

A

112

1

—ch2f

—ch2—s—ch2—ch2— —conh2-c2h5

A

113

1-ch3

—ch2—s—ch2—ch2—

—COOC2H5-c2h5

A

114

1

—ch3

, —ch2—s—ch2—ch2— —oc2h5-C2Hs

A

MMR spektrum

7,8-6,5m (8H); 2,9m (2H); 1,5m (2H); l,2d (3H)

3,0-2,6m + s (5H); l,5m (2H); l,2d (3H)

2.6- 2,3m (6H); l,8-l,2m (8H); l,2d (3H)

7,2-6,5m (9H); 2,4m (2H); l,5m (2H); l,2d (3H)

7.6- 6,5m (8H); 2,4m (2H); l,5m (2H); l,2d (3H)

7.2- 6,4m (8H); 3,9s (3H);

2,4m (2H); 1,5m (2H); l,2d (3H)

2,4m (2H); l,8-l,2m (8H); l,2d (3H)

2,4m (2H); l,8-l,2m (6H); l,2d (3H)

7,4-7,0m (9H) ; 2,7m (2H); l,2d (3H)

7.3- 6,8m (8H); 2,7m (2H); l,2d (3H)

2,4m (2H); l,2d (3H)

8.1- 7,lm (8H); 6,5bs (2H); 2,7m (2H); 1,3d (3H)

1.2- 6,lm (8H); 3,8s (3H); 2,7m (2H); l,6-l,2m (3H); l,Od (6H)

13,0s (1H); 7,8-6,8m (10H); 6,0bs (2H); 2,9-2,6m (4H)

8.2- 6,4m (14H); 2,9-2,6m (4H)

7.8- 6,4m (14H); 2,9-2,6m (4H)

7.3- 7,Om (8H); 2,7m (2H); 2,3s(3H); l,9-l,4m (3H); l,Od (6H)

7.3- 7,Om (9H); 3,9-3,Om + s (6H); 2,4m (2H); l,2d (3H)

7.3- 6,9m (9H); 2,6-2,3m (5H); 0,9d (6H)

2,6-2,2m + s (12H); l,2d (3H)

5,l-4,3m (5H); 2,5-2,2m (6H)

4,2q (4H); 2,5-2,2m (6H);

1,2d +1 (9H)

3.9- 3,Oq + m (8H); 2,4-2,2m (4H); 1,2d +1 (6H)

20