183321. lajstromszámú szabadalom • Eljárás béta-blokkoló hatású indol-származékok előállítására

183 321

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CH„N02

(71)

bci3

(1-0)-15 rt

2

55

65

3.

CH^Ph

(38)

BC13

(1.0)

♦1

13

k

/

/

4.

(ch2ci)2

(25)

BC13

(1-0)

n(c2h5)3

(i.o)-18 -> rt

42

27

33

5,

(ch2ci)2

(29)

BBr3

(i.o)

k<C2H5)3

(1.0)-18 0

30

/

/

6.

(ch2ci)2

(29)

A1C13

(1.0)

0 r t

24

/

/

7.

(ch2ci)2

(29)

A1C13

(1.0)

n(c2h5)3

I»

24

/

/

8

(ch2ci)2

(8)

BeCl2

(1.0)

k(c2h5)3

(2.2)-20 -> rt

50

31

4

/

/

9

(ch2ci)2

(45)

SnCl^

(3.5)

n(c2h5)3

(7.5)-78 -> rt

17

4l

48

10.

(CH^Cl)2 (25)

SnCl^

(2-5)

Sc2h5)3

(10.0)-20 -> rt

10

39

48

11.

CH^Pti

(25)

SnCl^

(3-5)

n(c2h5)3 (10.0)-70 rt

11

21

25

12,

CH2C12

(56)

SnCl^

(3.5)

N^n-C8H17^3

(3-0)

W

23

59

70

13.

CH2C12

(74)

SnCl^

(2.5)

C2H5N(C6Hli>2

(5-0)

«

43

10

12

14,

CH2C12

(66)

SnCl.

(2-5)

(*.o)-78 5

18

/

/

15.

CH2C12

(55)

SnCl^

(2.5)

(4.0)

tl

12

/

/

16.

CH2C12

(73)

SnCl^

(3-5)

ch3/^\) (5-0)

“70 -> rt

3

27

33

17.

CH2C12

(69)

SnC ij (2.5)

C2H5VJP (5’°;

••

46

/

/

18.

CH2CL2

(79)

SuC1l4

(2.5)

(CH.pj.NPl. ( 5.0)

“

4 i

/

/

3