176260. lajstromszámú szabadalom • Eljárás emkefelin-analóg polipeptidek előállítására
51 176260 52 18. táblázat Példa Tennék száma A B C Rf x 102 D F H K Q Kiind. anyag száma Módszer Megjegyzés 43. H—Me —1Tyr-D—Ser-Gly-Phe—Leu—OMe 68 77 62 58 44 9 103. E2. 1, 10 44. H—Me—Tyr—D—Ser(But)—Gly— —Phe—Leu—OMe 7 80 73 61 60 28 103. E2. 1, 10 45. H-Tyr-D-Ala-Gly-Phe—Azleu—NH2 68 79 64 58 41 30 80 145. E8. 1, 4, 14 46. H—Tyr—D—Alá—Gly—Phe—DL— —NH-(2-oxo-tetrahidrofur-3-il) 48 65 38 57 67 146. E9. 1, 12 47. H—Tyr—D —Alá—Gly—Phe— —Leu—OMe 67 49 21 162. E7. 1, 5, 15 48. H—Tyr—D—Ala—Gly—Phe—Leu— —NH—(ciklohexil) 67 58 45 87 10 172. E3. 1, 8, 16 49. H—Tyr-D-Ala-Gly-Phe-Leu—(tetrahidropirrolo) 65 62 44 96 173. El. L 8, 17 50. H—Tyr—D—Ala-Gly-Phe—Leu— -(morfolino) 62 88 174. El. 1, 11, 18 51. H—Tyr—D—Alá—Gly-Phe— -Met-OMe 62 79 61 60 62 54 84 147. E8. 1, 4, 19 52. H—Tyr—D—Alá—Gly—Phe— —Pro—NHEt 52 72 60 63 73 176. El. 1, 12 53. H—Tyr—D—Lys—Gly—Phe— -Leu-OMe 54 109. E2. 2, 8 54. H—Tyr—D—Met-Gly—Phe— —Leu-OMe 59 49 81 14 148. E5. 1, 7 55. H—Tyr—D—Ser-Gly-Phe— —Azleu-NH2 68 80 55 60 50 34 149. E8. 20 56. H—Tyr-D-Ser-Gly-Phe— —Leu-OMe 63 76 68 65 88 111. El. 1, 13, 9 57. H—Tyr—D—Ser—Gly—Phe—Leu— -(tetrahidropirrolo) 55 67 57 54 121. El. 1. 8 58. H—Tyr—D-Ser-Gly-Phe—Met-OMe 62 70 67 60 57 53 151. E8. 1, 6, 21 59. H—Glu-Tyr—D-Ala-Gly—Phe—Leu—OMe 58 68 202. El. 1, 8 60. H-Lys-Tyr-D—Ala-Gly— —Phe—Azleu—NH2 34 65 21 212. E8. 1, 6, 22 61. H—D—Lys—Tyr-D-Ala-Gly—Phe—Leu-OMe 54 10 65 206. E2. 2, 3 62. H-Lys-Tyr—D—Ala-Gly— —Phe—Leu-OMe 54 68 23 48 72 207. E2. 2, 11 26
