Dr. Murai Éva - Gubányi András szerk.: Parasitologia Hungarica 31. (Budapest, 1998)
Upma, J. A. és Banyai, H. S.: A Plasmodium berghei-ből nyert 24,000 g-os üledék IL-1 választ indukál egérben és véd a maláriás fertőzéssel szemben A szerzők egereket immunizáltak a Plasmodium berghei szakaszos centrifugálásából kapott üledékkel (SI és SIII). Az SIII üledék teljes védelmet indukált a fertőzéssel szemben. Az SIII saponinos emulziója bizonyult a legjobbnak, a beoltott egerekből származó szérum in vitro 89 %-ban gátolta a merozoiták invázióját és a szérumban emelkedett az IL-1 szint. A szerzők megvitatják a 24 000 g parazita komponens szerepét a malária elleni védelemben. REFERENCES Bailly, E., Savel, J., Mahouy, G. and Jaureguiberry, G. (1991): Plasmodium falciparum : Isolation and characterization of 55-Kda protease with a cathepsin -D like activity from P. falciparum. —Exp. Parasitol. 72:278-284. Bannister, L. H., Mitchell, G. H., Butcher, G. A. and Dennis, E. D. (1986): Lamellar membranes associated with rhoptries in erythrocytic merozoites of Plasmodium knowlesi: a clue to the mechanism of invasion. —Parasitol. 92:291-303. Banyai, H. S., Pandey, V C. and Dutta, G. P. (1979): Subcellular fractionation and localization of marker enzymes of erythrocytic stages of Plasmodium knowlesi. —Indian J. Parasitol. 3:9-14. Banyai, H. S., Pandey, V. C. and Dutta, G. P. (1980): Acid and alkaline phosphatases of Plasmodium knowlesi. Indian —/. Parasitol. 4:127-134. Banyai, H. S., Misra, G. C, Gupta, C. M. and Dutta, G. P. (1981): Involvement of malarial proteases in the interaction between the parasite and host erythrocyte in Plasmodium knowlesi infection. — / Parasitol. 67:632-626. Banyai, H. S., Pandey, V. C. and Dutta, G. P. (1982): Proteinases of Plasmodium knowlesi. — Indian J. Malariol. 19:73-82. Bernard, F. and Schrevel, J. (1987): Purification of a Plasmodium berghei neutral endopeptidase and its localization in merozoites. — Mol. Biochem Parasitol. 26:167-174. Collins, W. E. and Skinner, J.C. (1972): The indirect fluorescent antibody test for malaria. — Am. J. Trop. Med. Hyg. 21:690-695. Curfs, H. A. J., Vander Meer, J. W. M., Saverwein, R. W. and Eling, W. M. C. (1990): Low dosages of interleukin 1 protect mice against lethal cerebral malaria. — J. Exp. Med. 172:1287-1291. Ferma, B., Becker, P., Schaffar, L., Shaw, A. and Fehlmann, M. (1988): Detection of human IL-1 at the subpicomolar level by colorimetric sandwich enzyme immunoassay. —/. Immunol. Methods 114:41-48. Fiske, C. H. and Subba Row, Y. (1925): The colorimetric determination of phosphorus. —/. Biol. Chem. 66:375-400. Freeman, R. R. and Holder, A. A. (1983): Characteristics of the protective response of Balb/C mice immunized with a purified P. yoelii schizont antigen. — Clin, and Expt. Immunol. 54:609-616. Goldberg, D. E., Slater, A. F. G., Cerami, A. and Henderson, G. B. (1990): Hemoglobin degradation in malaria parasite Plasmodium falciparum', an ordered process in a unique organelle. —Proc. Natl. Acad. Sei. USA. 87:2931-2935. Hadley, T., Aikawa, M. and Miller, L. H. (1983): Plasmodium knowlesi: studies on invasion of rhesus erythrocytes by merozoites in the presence of protease inhibitors. —Exp. Parasitol. 55:306-309. Holder, A. A ..and Freeman, R. R. (1991): Immunization against blood-stage rodent malaria using purified parasite antigens. — Nature 294:361-364. Jeffery, G. M. (1966): Epidemiological significance of repeated infections with homologous and heterologous strains and species of Plasmodium. —Bull. WHO 35:873-882.