Dr. Murai Éva szerk.: Parasitologia Hungarica 14. (Budapest, 1982)

><>1 LKALOIDA DELAGI Antimalaricum, antirheumaticum TABLETS and SYRUP Chloroquin is a significant representative of the synthetic antimalaria drugs. In tropical and subtropical areas it is an important preparation against malaria caused by protozoans. Due to its water solubility It is well absorbed from the gastrointestinal tract, it shows selective affinity to liver tissue. It is the most extensively used drug against acute attacks. Primarily the chloroquin acts on the erythrocytic (schizoite) stage of the Plasmodium, presumably by glucocorticoid mobilization. It is less effective on the exo-erythrocytic stages of Plasmodium. According to this the compound is mainly applicable for supressing and preventing attacks. As a results of the treatment the symptoms of the disease do not appear, fever attacks do not occur. INDICATIONS SIDE EFFECTS Oral treatment is usually employed and is Headache, visual disturbance, gastrointestinal to be preferred. complaints. DOSAGE Suppresion and prevention: The administration of DELA GIL should be commenced one week before arrival in the endemic area and should be continued for 4 weeks after leaving. In areas with a high risk and where malignant malaria (P. falciparum) occurs, it is advisable to administer the recommended dose twice weekly. For prevention: Adults: 2 tablets once weekly, taken on the same day each week. Infants and children: the following doses must be taken once a week, regularly. Age Dose (syrup, measuring spoonful) under 1 year 1-3 years 3-6 years 6-9 years 9-12 years For tr e a tm ent : a) Tablets 0.5 1 1.5-2 2-2.5 2.5-4 Children (6-12 years) Adults First day: Initial dose 6 hours later 2 tablets 1 tablets 1 tablet 1 tablet 4 tablets 2 tablets 2 tablets 2 tablets Second day: Third day: In semi-immune patients, i.e. natives of malarial areas, a single doseof 4 tablets will usually achieve complete control of any acute malarial attack. b) Syrup The initial dose is the same as given in the above table. 6 hours later and in the next 2 days the daily dose of the syrup is: under 1 year max. 0.5 measuring spoonful 1-6 years 1 measuring spoonful 6-12 years 1.5 measuring spoonful COMPOSITION Each DELAGIL tablet contains 250 mg of chloroquine phosphate, equivalent to 150mgof chloroquine base. Each 5 ml of DELAGIL syrup contains 125 mg of chloroquine phosphate, equivalent to 75 mg of chloroquine base. Manufactured by ALKALOIDA CHEMICAL WORKS H-4440 Tiszavasvári, Hungary Exported by MEDIMPEX Hungarian Trading Company for Pharmaceutical Products H-1808 Budapest, PO.B. 126. Hungary V,< X x x X x X X X •> cx >< >< XX XX X ><><><:><><.!><><; x x x>< X ><>< >< >< >< ;>< »O<Í><»<»<Í><>0 ^