Dr. Kassai Tibor - Dr. Murai Éva szerk.: Parasitologia Hungarica 8. (Budapest, 1975)

Treatment with BHC1 gave inconclusive results in wiew of the great range of variation of worm counts seen in the 5 dogs of Group J. NA at 500 mg/kg showed limited efficiency resulting in substantial worm reduction in 4 (28 per cent) of the treated 14 dogs only (Group C). Similary, little activity against E. granulosus was shown in either Groups G and I dosed by 200 mg/kg of cantrodifene. (In Exps. 2 and 3 "Lopatol" tablets of different code numbers were used.) This drug proved active in 2 of 16 dogs (14 per cent) only. FIELD TRIALS From the data of Table 3 it is seen that biscuits containing BHN were readily consumed by the non excited dogs. Previous starvation was apparently not needed. Neither vomiting nor other side effects were manifest within 1 hour after treatment. The 98,3 and 88, 5 per cent total consumption of biscuit A and B, respectively, indicate that the palatability of formulation A is superior to that of B. Table 3 Palatability field trial with BHN in biscuit formulation Biscuit A Biscuit B Total number of dogs 122 35 Dogs consuming total dose 120 31 immediately 115 30 within 15 minutes 2 1 within 1 hour 3 0 Dogs consuming a part of the dose 1 1 Dogs refusing consumption 1 3 Discussion The few reports on the action of bunamidine hydroxynaphthoate against mature (8 to 9-week old) E. granulosus recommend 2 doses given at 2 or 4 days interval in the food at a dose level of 12, 5 to 64 mg/kg (SHEARER and GEMMEL, 1969; GEMMEL and OUDEMANS, 1974/a). This course of treatment may reduce worm burden by 99,8 per cent in the average. No increase of efficiency occurred when the level was raised to 100 mg/kg (SHEARER and GEMMEL, 1969). Complete elimination of all Echinococcus is obtainable by additional treatments rather than by giving higher doses. It has been calculated that in order to achieve a "one hit" absolute kill of worms, an inapplicable rate exceeding 400 mg/kg may be needed (GEMMEL and OUDEMANS, 1974/a). Against immature, 3 to 4-week old worms a 91 per cent reduction has been shown by a 2x50 mg/kg treatment (SHEARER and GEMMEL, 1969) and against 5-week old worms a 100 per cent efficacy of the same dose level has been reported (NIKITIN et al., 1973). It has also been observed that untoward sequelae such as vomiting and diarrhoea occur more frequently following the second rather than the first treatment (SHEARER and GEMMEL, 1969). This study attempted to define the efficacy of a single high dose level treatment with bunamidine hydroxynaphthoate and to test a formulation which may facilitate massive application of the drug in control schemes. The results obtained demonstrate that a single treatment at 100 mg/kg is highly effective against 6-week old worms, though normally is not expected to cause elimination of