Dr. Kassai Tibor szerk.: Parasitologia Hungarica 1. (Budapest, 1968)

nem találtak. E tapasztalatok nem támasztják alá a homocytotrop ellenanyagoknak a parazitás immunitásban játszett közvetlen szerepére vonatkozó feltevéseket. SZEPES, G. — KASSAI T.: An Investigation by Passive Cutaneous Anaphylaxis (PCA) Test of the Connection between Homocytotropie (reagin-type) Antibodies and Parasitic Immunity In the serum of hosts infected by certain parasites, the presence of homocytotropie (reagin-type) antibodies has been demonstrated but their role in parasitic immunity cannot be interpreted unequivocally on the basis of experimental findings up to now. In the course of two experimental series, the authors exposed 121 rats to early or late Infections by N. brasiliensis inducing immunological tolerance and a primary immune reaction,respectively

. An attempt was made to study the relationship between the homocytotropie antibody titre of the serum.measured by 72-hour passive cutaneous anaphylaxis (PCA) test and the immunological state of the individual hosts assessed by worm recoveries. After the primary immune reaction, no or only very low titres of reagin-type antibodies could be demonstrated in mature rats. PCAactive antibodies were, however, also demonstrable in.the sera of neonatally infected and immunologically tolerant animals. Homologous reinfection of hosts first exposed to neonatal infection led to an anamnestic increase of the homocytotropie antibody level, but this was not coincident with cessation of tolerance.No Interrelationship was found between the PCA-titre of the sera of individual rats and their immunological state (tolerant, immune, doubtful). These findings failed to corroborate assumptions concerning the direct role of homocytotropie antibodies in parasitic immunity

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