Kapronczay Károly szerk.: Orvostörténeti Közlemények 188-189. (Budapest, 2004)

TANULMÁNYOK - ARTICLES - Buzás György Miklós: A helicobacter pylori felfedezésének története

(tuberculosis, cholera, dysentery, syphilis) was ascertained. In spite of many bactériologie, experimental, biochemical and therapeutic observations, the causative role of the microorganism in the pathogenesis of peptic ulcer was not recognised even in the case of most elegant demontrations. Sometimes, head-strong thinking and excessive belief in opinion leaders statements set back the bacterial research. The identification of Helicobacter pylori by Barry J.Marshall and J. Robert .Warren in 1983 can not be, in any case, considered as serendipitous: without the endeavour, youthful curiosity, talent and ambition of the former and solid classical knowledge in pathology of the latter, peptic ulcer might be considered even today as an acid-related or psychosomatic disease, as it was during the past century. IRODALOM 1. Baume, P.E.- Nicholls, A.- Baxter, CH.: Inhibition of gastric acid secretion by a purified bacterial lipopolysaccharide. Nature, 1967. 215,59-60. 2. Bizzozero, G.: Sulle ghiandole tubulari del tubo gastro-enterico e sui raporti del loro epitelio coll'epitelio di rivestimenti della mucosa. Atti della Reale Accademia delle Scienze di Torino. 1892. 28,233-251. 3. Boas, L: Diseases of the Stomach. Philadelphia Davis, 1907. 4. Bókay A.- Kéthly, K.: Emésztési szervek betegségei. A belgyógyászat kézikönyve. (Szerk. báró Korányi Frigyes). Budapest, Athaeneum, 1896, 3. kötet. 5. Búzás Gy. M.: Helicobacter pylori. Medicina Könyvkiadó Rt., Budapest, 1998. 6. Chirica, L.C.- Elleby, B.- Lindskog, S.: Cloning, expression and some propertiers of alfacarbonic anhydrase from Helicobacter pylori. Biochim. Biophys. Acta, 2001. 1544, 55-63. 7. Cruveilhier J.: Considerations générales sur les ulcérations folliculaires de l'estomac, in: Atlas de V

Anatomie Pathologique. Bailliere, Paris, 1842. 8. Csiszár, K.- Gyepes P.- Bujalka, R.: Campylobacter pyloridis kimutatása gyomor biopsziás anyagból. Orv.Hetil. 1987. 128, 1419-1421. 9. Davenport, H.W.: A History of Gastric Secretion and Digestion. Oxford University Press, New York, 1992. 10. Doenges, J.L.: Spirochetes in Gastric glands of Macaccus rhesus and humans without definitehistory of related disease. Proc. So. Expl. Biol. Med. 1938. 38, 536-538. 11. Dragstedt, L.R.: Contribution to the physiology of the stomach. Gastric juice in duodenal and gastric ulcers. JAMA, 1917. 68, 330-333. 12. Döbrönte Z.- Lakatos F.- Brittig, F. et. al.: Van-e klinikai relevanciája a Campylobacter pylori infekciónak? Metodikai, epidemiológiai és klinikai vizsgálatok. Or\>. Hetil. 1989. 130, 2563-2568. 13. Edkins, J.S.: Spirella regaudi in the cat. Parasitology, 1923. 12, 296-298. 14. Erdei A.- Győri I.- Kazsuba A. et al. Antibakteriális kezelés Campylobacter pylori pozitív gastroduodenalis kórképekben. Magyar Belorv. Arch. 1988.41, 167-173. 15. Fantini B.: La microbiologie médicale, in: Histoire de la pensée médicale en occident, 3. Du romantisme a la science moderne. M.D.Grmek (red.). Éditions du Seuil, Paris, 1999. 115-146.