Hidrológiai Közlöny 1988 (68. évfolyam)

4. szám - Varga Csaba: A testvérkromatid-csere (SCE) analízis alkalmazása a vízminőség-vizsgálatban

VARGA CS,: SCE analízis a vízminősígvizs,gálatban 235 Care, R., Morrison, J. D., Smith, J. F., 1982. On the limits of detection of traces of volatile organics in water, using Amberlite XAD

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id-csere (SCE) analízis, mint környezetbiológiai vizsgálómódszer, es alkalmazásai humán vizsgálatokban. Egyetemi doktori értekezés, KLTE TTK, Debrecen. Varga Cs., 1987b. Felszíni vízből előállított ivóvíz genotoxicitás-vizsgálata in vitro SCE és in vivo kromoszóma aberrációs teszttel. Magyar Hidrol. Társ. VII. orsz. vándorgyűlése, Salgótarján, III. Regionális vízművek, MHT, Budapest, pp. 197—20,". Varga, Cs., 1988. Chlorinated drinking water XAD isolates did not affect the sister chromatid exchange frequency. Int. Arch. Occup. Environ. Health Sei. (közlés alatt) Wolff, S., 1983. Sister chromatid exchange as a test for mutagenic carcinogens. Ann. NY Acad. Sei., 93: 142—153. Kézirat beérkezett: 1987. december 17. Átdolgozás beérkezett: 1988. február 2. Közlésre elfogadva: 1988. április 1. Application of the sister chromatid exchange (SCE) analysis to water hygiene. Part 1. Studies on XAI) isolates of chlorinated drinking water in human peripheral lymphocyte system Varga, Cs. Abstract: Sister chromatid exchanges (SCEs) are apparently reciprocal interchanges between differently dyed sister chromatids of M2 chromosomes (Fig. 1.). For most chemicals this cytogenetic end-point has proved to be a far more sensitive indicator of whether or not a cell has been exposed to mutagen-carcinogens (genotoxins) than chromosomal aberrations. Because of its sensitivity and ease of scoring the SCE-analysis has been used increasingly as a short-term test for the detection of environmental genotoxins, and an excellent qualitative correspondence has been found between induced SCEs and gene mutations. The induction of SCEs in human lymphocytes has also been used as a