Fogorvosi szemle, 2006 (99. évfolyam, 1-6. szám)
2006-04-01 / 2. szám
FOGORVOSI SZEMLE ■ 99. évf. 2. sz. 2006. 60-82. AZ MFE FOGPÓTLÁSTANI TÁRSASÁGA XVI., A MAGYAR FOGORVOSOK IMPLANTOLÓGIAI TÁRSASÁGA VI., A MAGYAR PARODONTOLÓGIAI TÁRSASÁG XIV. KONGRESSZUSÁN ELHANGZOTT ELŐADÁSAINAK ABSZTRAKTJAI 2005. OKTÓBER 13-15. SOPRON DR. Á. BÁN,1 DR. É. GÖMÖRI,* 1 2 DR. E. PINTÉR3 * • 1 School of Dentistry, Pécs;2 Department of Pathology, Faculty of Medicine, University of Pécs;3 Department of Pharmacilogy and Pharmacotherapy, Faculty of Medicine, University of Pécs MODULATORY ROLE OF CAPSAICIN-SENSITIVE SENSORY NERVE FIBRES IN PATOMECHANISM OF ORAL LICHENOID REACTIONS Introduction: Pro-inflammatory and anti-inflammatory neuropeptides released from sensory fibres innervating oral mucosa by different stimuli play modulatory role in the chronic inflammatory diseases of oral mucosa such as lichen oris and lichenoid reactions. Previous studies have supposed that mercury content of amalgam filling influences the development of oral lichenoid reactions. The aim of the present study was 1. To investigate the effect of chronic amalgam exposition on oral mucosa in animal models and examine the interactions of neurogenic components. 2. To make histological analyses of oral mucosa biopsies from patients suffering from lichen oris and lichenoid reactions and to prove the existence of neurogenic factors. Methods: 1. Capsaicin-sensitive sensory fibres were desensitised with systemic capsaicin pre-treatment in newborn Wistar rats to exclude the neurogenic interactions. Sevenweek-old pre-treated and control animals were involved into the experiment. Buccal mucosa was painted with 0.2% HgCI2 dissolved in glycerol every other day for 8 weeks. At the end of the treatment the animals were killed, and treated oral mucosa pieces were dissected for histological examinations. 2. Clinical diagnosis of lichen oris or lichenoid reaction were confirmed by histological analysis in patients with amalgam filling. Immunhistochemical studies have been started to show the changes of TRPV1 -receptor (capsaicin receptor) density in tissue samples of the patients. Results and conclusions: Histopathological changes induced by HgCI2 painting were deteriorated after capsaicin pre-treatment. We presume that capsaicin-sensitive sensory neurons exert protective influence on the development of lichenoid reactions. Further studies focus to elucidate the role of neurogenic components in these inflammatory processes using human and rat tissue samples. Supported by: OTKA 046729, ETT 05-598/2003 DR. M. BANDULA,1 DR. T. SZABÓ,2 DR. E. MONOKI,2 DR. I. VAJDOVICH1 1 Dr. Bugyi István Hospital, Szentes, Department of Operative Dentristry; 2 Dr. Bugyi István Hospital, Szentes, Department of Radiology THE ROLE OF DUAL-SLICE SPIRAL CT IN IMPLANTOLOG1CAL PLANING Jaw bones are constituted of the mandible and maxilla, two bones with complex spatial relationships. It is impossible to judge bone supply precisely from 2-dimensional X-ray shots. Thus implantological planning is uncertain. The adequate software-assisted processing of modern imaging procedures, spiral CT scans, and the data gained from these scans offer significant assistance in implantological planning. The advantages of dual spiral CT, Denta PC reconstruction are: • 3D and reconstruction opportunities from different directions • precise judging of the spatial extension of jaw bones, based on measurements • precise determination of the location of anatomical formulae that pose risk • determination of jaw bone quality on the basis of density. At the Dr. Bugyi István Hospital in Szentes we have had at our disposal a General Electric Hispeed NX/i dual spiral CT scanner and a Denta PC programme for processing the data since 01/01/2004. Denta PC enables us to reconstruct from CT scan data panoramic images and sagital slice images on which we are able to take precise measurements to understand jaw bone supply. Between 01/01/2004 and 01/05/2005, we carried out spiral CT scans on 63 occasions in order to judge extensive jaw bone deficiency with precision. Through the reconstructions that emerged from Denta PC software, we were able to map jaw bone supply pre-operatively, thus it was possible to plan with precision the operation and the extent of bone prosthesis. Out of the 63 patients, 12 had their jaw bone reconstructed with their own bone extracted from hip bones. In the other 51 cases, the jaw bone spine was reconstructed with their own bones extracted from intraoral areas, primarily the mentum. Our lecture relies on some of our cases to give an account of our experiences and results achieved so far.
