Fogorvosi szemle, 2006 (99. évfolyam, 1-6. szám)

2006-12-01 / 6. szám

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FOGORVOSI SZEMLE ■ 99. évf. 6. sz. 2006.

group (p < 0.03), apart from the three months implanthealing time.

Conclusion: A higher grade of anchorage stability and a shorter treatment period was achieved by fastening the anchorage teeth to a PI, compared to a conventional dental anchorage. For the challenges in daily practice, the PI offers higher treatment predictability and security for clinicians and patients.

SIALOLOGY IN THE FOCUS OF BIOMEDICAL RESEARCH. THE IMPACT OF SALIVARY DIAGNOSTICS MONITORING THE ORAL AND SYSTEMIC HEALTH

BOROS, I., KESZLER, P„ ZELLES, T.

Department of Oral Biology, Faculty of Dentistry, Semmelweis University, Budapest, Hungary

Until early in 2000 the serum and urinary analysis served mainly to measure human general health. In spite of this fact application of saliva as a diagnostic fluid had also a considerable but underscored history. In the past two decades there has been growing appreciation of saliva detecting HIV, HCV infections, drug abuse, monitoring the hormonal status, etc. Due to the adaptation of the latest methods of molecular biology, progress in technology and diagnostics, and collaborations among experts of different specialties, saliva might be the most acceptable noninvasive diagnostic medium in this century. Identification of specific salivary biomarkers by using nanotechnology and biosensors might change the trend, as well as facilitate monitoring the general and oral health, disease onset, progression and the outcome of treatment. Now we have arrived in the era focused on the search of definitive disease-associated salivary protein and genetic markers as suggested and initiated by NIDCR in 2002- 2003 (1). With the most modern and sensitive techniques, 309 and 437 proteins, respectively, have been recently identified in human saliva (2,3). Different human mRNAs (approximately 3000) were also discovered and profiled in 2004 (4). Nearly 180 of that mRNAs were published to be common between healthy subjects (NTSC: normal salivary transcriptome core). In addition, four informative RNA biomarkers were found to be good candidates for detecting oral cancer. Intense research aims to create and complete a comprehensive human salivary protein library until 2008. It is supposed that due to these efforts valuable data will be soon available for a number of specific salivary biomarkers that reflect different oral and systemic diseases (e.g. oral and breast cancer, Sjogren’s syndrome, dental caries, periodontitis, cardiovascular disorders, infectious diseases, diabetes mellitus, etc.). Wide range of collaborations among different researchers studying saliva will substantially contribute

to the appreciation of saliva as a diagnostic fluid. Research efforts on this field forced to establish a new discipline termed sialology, as Glick proposed this year

(5). The close connections existing between dentistry and general medicine are further evidenced by the findings illustrated in the frame of this lecture. However, from a clinical standpoint dentists should be aware of not only the importance of their profession but also the need to further educate themselves in this topic.

1. Wong DT: Salivary diagnostics powered by nanotechnologies, proteomics and genomics. JADA 2006; 137: 313-321.

2. Hu S, Xie Y, Ramachandran P, Loo RRO, Li Y, Loo JA, Wong DT: Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry. Proteomics 2005; 5: 1714-1728.

3. Xie H, Rhodus NL, Griffin RJ, Carlis JV, Griffin TJ: A catalogue of human salivary proteins identified by free flow electrophoresis-based peptide separation and tandem mass spectrometry. Molec Ceil Proteomics 2005;4:1826-1830.

4. Li Y, Zhou X, St. John MAR, Wong DTW: RNA profiling of cell-free saliva using microarray technology. J Dent Res 2004; 83: 199-203.

5. Click M: Sialology, and who owns saliva anyway? JADA 2006; 137: 282-283.

ANATOMICAL CHANGES IN THE STRUCTURE OF TEMPOROMANDIBULAR JOINT INVESTIGATED IN EDENTULOUS PATIENTS

CSADÓ, «., SCHMIDEG, GY., KIVOVICS, P.

Prostodontic Department, Faculty of Dentistry, Semmelweis University, Budapest, Hungary

Introduction: According to the clinical experience, the angle of the posterior slope of articular eminence of totally edentulous patients, compared to that of patients with maintained occlusion, show significant decrease. Aim of the study: The aim of our study was to reveal whether there is a measurable correlation between edentulousness and the anatomic deformation of articular eminence, or this decline is just a physiological change in the elderly population.

Subjects and methods: We examined and compared the articular eminence of three different groups of each consisting of 10 patients (Group I: 18-25 years-old patients with maintained occlusion, Group II: patients over 60 with maintained occlusion, Group III: edentulous patients over 60). The measurements were carried out on orthopantomographs (OPG) taken with Kodak 8000 (Trophypan) Digital Dental Orthopantomogram. On the OPG we measured the angle of the posterior