Fogorvosi szemle, 2006 (99. évfolyam, 1-6. szám)
2006-08-01 / 4. szám
139 FOGORVOSI SZEMLE ■ 99. évf. 4. sz. 2006. 10. Longo F, Califano L, Mangone GM, Errico ME: Neuroendocrine (Merkel cell) carcinoma of the oral mucosa: report of a case with immunohistochemical study and review of the literature. J Oral Pathol Med 1999; 28: 88-91. 11. Meland NB, Jackson IT: Merkel cell tumor: diagnosis, prognosis and management. Plast ReconstrSurg 1986; 77: 632-638. 12. Mir R, Sciubba J, Bhuiya T, Blomquist K, Zelig D, Friedman E: Merkel cell carcinoma arising in the oral mucosa. Oral Surg Oral Med Oral Pafbo/1988; 65: 71-75. 13. Murphy Jr R, Li JK, Mincer FK, Strauch B: Trabecular (neuroendocrine) carcinoma of the skin. Report of four cases and review of literature. NY State J Med 1990; 90: 35-38. 14. Pitale M, Sessions RB, Husain S: An analysis of prognostic factors in cutaneous neuroendocrine carcinoma. Laryngoscope 1992; 102: 244-249. 15. Ratner D, Nelson BR, Brown MD et al: Merkel cell carcinoma. J Am Acad Dermatol 1993; 29; 143-156. 16. Rice RD, Chonkich GD, Thompson KS et al: Merkel cell tumor of the head and neck: Five new cases with literature review. Arch Otolaryngol Head Neck Surg 1993; 119: 782-786. 17. Schmidt-Westhausen A, Reichert PA, Gross UM: Gingival metastasis of Merkel cell carcinoma: a case report. J Oral Pathol Med 1996; 25: 44-47. 18. Shaw JHF, Rumball E: Merkel cell tumour: clinical behaviour and treatment. Br J Surg 1991; 78:138-142. 19. Sibley RK, Dehner LP, Rosai J: Primary neuroendocrine (Merkel cell?) carcinoma of the skin. I. Aclinicopathologic and ultrastructural study of 43 cases. Am J Surg Pathol 1985; 9: 95-108. 20.Silva EG, Mackay B, GoepfertH, Burgess MA, Fields RS: Endocrine carcinoma of the skin (Merkel cell carcinoma). Pathol Ann 1984; 19:1-30. 21. Slaughter DP, Southwick HW, Smejkal W: „Field cancerization” in oral stratified squamous epithelium. Cancer 1953; 6: 963-968. 22. Soanes WA, Ablin RJ, Gonder MJ: Remission of metastatic lesions following cryosurgery in prostatic cancer: immunologic considerations. JUrol 1970; 104:154-159. 23.SONKODI I: Kriosebészet az orofacialis régióban. Semmelweis Kiadó, Budapest, 2000; 137-190. 24.SONKODI I: Orális Medicina. Semmelweis Kiadó, Budapest, 1993; 165-166. 25-Toker C: Trabecular carcinoma of the skin. Arch Dermatol 1972; 105: 107-110. 26. VIGNESWAREN N, MÜLLER S, LENSE E, STACEY B, HEWAN-LOWE K, Weathers DR: Merkel cell carcinoma of the labial mucosa. An immunhistochemical and ultrastructural study with a review of the literature on oral Merkel cell carcinomas. Oral Surg Oral Med Oral Pathol 1992; 74: 193-200. 27. Yoshida H, Onizawa K, Hirohata H: Neuroendocrine carcinoma of the tongue: report of a case. J Oral Maxillofac Surg 1995; 53: 823- 827. Dr.Nagy J, Dr. Iványi B, Dr. Sonkodi I Merkel Cell Carcinoma Merkel cell carcinoma (Mcc) is a very rare, malignant, neuroendocrine tumour. Mcc has an aggressive behavior, local reccurence, and regional or distant metastasis generally develop within a short period of time. At the Oral Medicine Departement 158,056 patients were treated between 1970 and 2004. A single case of Mcc was diagnosed, in a 79-year-old woman. The tumour was localized to the upper lip. After successful cryosurgery and a 7-year tumour-free period, a new tumour developed in her palatine tonsil. It was an anaplastic carcinoma with neuroendocrine features, raising the possibility of a late haematogenous metastasis, a second field tumour, or a second primary tumour. The clinical, histological, immunhistochemical and genetic findings suggested that the tumour of the palatine tonsil is a second field tumour. Key words: Merkel cell carcinoma, cryotherapy, second field tumour, immunhistochemical study, differential diagnosis
