Fogorvosi szemle, 2004 (97. évfolyam, 1-6. szám)
2004-08-01 / 4. szám
149 FOGORVOSI SZEMLE ■ 97. évf. 4. sz. 2004. 6. KalkWWI, Raghoebar GM, Jansma J, BoeringG: Morbidity from iliac crest harvesting. J Oral Maxillofac Surg 1996; 54:1424-I429. 7. Kovács K, Velich N, Huszárt, Szabó G, Semjén G, SubaZs: Comparative study of ß-tricalcium phosphate mixed with platelet-rich plasma versus ß-tricalcium phosphate, a bone substitute material in dentistry. Acta Vet Hung 2003; 51: 475-484. 8. Liu YL, Schoenaers J, De Groot K, De Wijn JR, Schepers E: Bone healing in porous implants: A histological and histomorphometrical comparative study on sheep. J Mater Sei Mater Med 2000; 11: 711-717. 9. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Gerogeff KL: Platelet rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol 1998; 85: 638-646. 10. Marx RE, Garg AK: Bone graft physiology with use of platelet-rich plasma and hyperbaric oxygen. Chapter 16. In: The Sinus Bone Graft. Editor: Jensen OT, Quintessence Publishing Co. Inc. Chicago, 1999; 183-189. 11. McAllister BS, Margolin MD, Cogan AG, Buck D, Hollinger JO, Lynch SE: Eighteen-month radiographic and histologic evaluation of sinus grafting with anorganic bovine bone in the chimpanzee. IntJ Oral Maxillofac Implants 1999; 14: 361-368. 12. Moy PK, Lundgren S, Holmes RE: Maxillary sinus augmentation: histomorphometric analysis of graft materials for maxillary sinus floor augmentation. J Oral Maxillofac Surg 1993; 51: 857-862. 13. Nicolas RW, Lange TA: Granular tricalcium phosphate grafting of cavitary lesions in human bone. Clin Orthopedics and Related Res 1994; 206: 197-203. 14. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR: Bone histomorphometry: standardisation of nomenclature, symbols, and units. J Bone Mineral Res 1987;2:595-610. 15. Ross R, Raines EW, Bowen-Pope DF: The biology of platelet derived growth factor. Cell 1986; 46:155-169. 16.Saffar JL, Colombier ML, Detienville R: Bone formation in tricalcium phosphate filled periodontal intrabony lesions. Histological observations in humans. J Periodontol 1990; 61: 209-216. 17. Schliephake H, Knebel JW, Aufderheide M, Tauscher M: Use of cultivated osteoprogenitor cells to increase bone formation in segmental mandibular defects: an experimental pilot study in sheep. Int J Oral Maxillofac Surg 2001 ; 30: 531-537. 18. StahlS, From S: Histological evaluation of human intraosseous healing responses to the placement of tricalcium phospate ceramic implants. I. Three to eight months. J Periodontol 1986; 57: 211-217. 19. Suba Zs, HrabákK, Huys L, Coulthard P, MaioranaC, Garagiola U, Szabó Gy: A ß-trikälcium foszfát csontregeneráló hatásának hisztológiai és hisztomorfometriai vizsgálata. Multicentrikus tanulmány. Orvosi Hetilap 2004; 145: 25-31. 20. Szabó Gy, SubaZs, Hrabák K, Barabás J, Németh Zs: Autogenous bone versus ß-tricalcium phosphate graft alone for bilateral sinus elevations /2- and 3-dimensional computed tomographic, histologic, and histomorphometric evaluations/: preliminary results. Int J Oral Maxillofac Implants 2001; 16: 681-692. 21. Tadjoedin ES, de Lange GL, Holzmann PJ, Kuiper L, Burger EH: Histological observations on biopsies harvested following sinus floor elevation using a bioactive glass material of narrow size range. Clin Oral Impl Res2000; 11: 334-344. 22-Terheyden H, Jepsen S, Möller B, Tucker MM, Rueger DC: Sinus floor augmentation with simultaneous placement of dental implants using a combination of deproteinized bone xenografts and recombinant human osteogenic protein-1. Clin Oral Impl Res 1999; 10: 510-521. 23. ZECHNER W, Tangl S, Tepper G, Fürst G, Bernhart Th, Haas R, Mailath G, Watzek G: Influence of platelet-rich plasma on osseous healing of dental implants: a histologic and histomorphometric study in minipigs. Int J Oral Maxillofac Implants 2003; 18:15-22. 24. Zerbo IR, Bronckers ALJJ, de Lange GL, van Beek GJ, Burger EH: Histology of human alveolar bone regeneration with a porous tricalcium phosphate. A report of two cases. Clin Oral Impl Res 2001; 12: 379-384. 25. Yildirim M, Spiekermann H, Biesterfeld S, Edelhoff D: Maxillary sinus augmentation using xenogenic bone substitute material Bio- Oss® in combination with venous blood. A histologic and histomorphometric study in humans. Clin Oral Impl Res 2000; 11:217-229. Dr. Suba Zs, Takács D, Dr. Gyulai-GaAl Sz, Dr. Kovács K, Dr. Velich N, Szigeti K, Dr. Szabó Gy: Alveolar bone regeneration stimulated by a combination of platelet-rich plasma and Cerasorb graft in Beagle dogs. Histological and histomorphometric studies Healing of extraction wounds was examined in an animal experiment model on Beagle dogs. After bilateral extraction of the premolars of 12 dogs the alveoli were filled up with a combination of ß-tricalcium phosphate (Cerasorb) graft and platelet rich plasma (PRP) on the experimental side, and with Cerasorb alone on the control side. Biopsy specimens were taken from the regenerating bone at 6, 12 and 24 weeks after surgery for histological study. Results of the histologic and histomorphometric examinations revealed that after 6 weeks the newly formed bone was significantly denser on the experimental side. After 12 weeks this difference became moderate, and after 24 weeks the bone forming activity was nearly equal on the two sides. These results suggest that local administration of Cerasorb and PRP results in more intense bone regeneration, especially in the early phase. Keywords: ß-tricalcium phosphate, platelet-rich plasma, bone regeneration, histology, histomorphometry, animal experiment
